2P5E
Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC Reveal Native Diagonal Binding Geometry
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31951.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11853.3 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (C) | Cancer/testis antigen 1B | polymer | 9 | 1094.3 | 1 | UniProt (P78358) | L antigen family member 2, LAGE-2 protein, Autoimmunogenic cancer/testis antigen NY-ESO-1 | |
| 4 | D (D) | T-Cell Receptor, Alpha Chain | polymer | 195 | 21406.8 | 1 | UniProt (A2NVQ1) Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 5 | E (E) | Hypothetical protein | polymer | 242 | 27218.3 | 1 | UniProt (Q2YDB4) | Homo sapiens (human) | |
| 6 | F, G, H, I, J... (A, B, E) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 7 | K (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 8 | L, O, P, Q, R (B, D, E) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 9 | N (C) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 10 | S (E) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 11 | V, W, X, Y, Z (A, B, C, D, E) | water | water | 18.0 | 739 | Chemie (HOH) |
Sequence modifications
B: 2 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | insertion |
| Cys 91 | Lys 111 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 93524.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1539.8 | |
| All* | Total formula weight | 95063.8 |
