2OO0
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ornithine decarboxylase | polymer | 471 | 52326.2 | 2 | UniProt (P11926) Pfam (PF00278) Pfam (PF02784) | Homo sapiens (human) | ODC |
| 2 | C, D, H (A, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 3 | E, I (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 4 | F, J (A, B) | 3-AMINOOXY-1-AMINOPROPANE | non-polymer | 90.1 | 2 | Chemie (XAP) | |||
| 5 | G, K (A, B) | PENTANE-1,5-DIAMINE | non-polymer | 102.2 | 2 | Chemie (N2P) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 523 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 461 (UniProt: P11926)
| PDB | External Database | Details |
|---|---|---|
| Ala -9 | - | cloning artifact |
| Gly -8 | - | cloning artifact |
| Glu -7 | - | cloning artifact |
| Asn -6 | - | cloning artifact |
| Leu -5 | - | cloning artifact |
| Tyr -4 | - | cloning artifact |
| Phe -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| Leu 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 104652.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1056.0 | |
| All* | Total formula weight | 105708.5 |
