2OO0
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001822 | biological_process | kidney development |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004586 | molecular_function | ornithine decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006595 | biological_process | polyamine metabolic process |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009615 | biological_process | response to virus |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0033387 | biological_process | putrescine biosynthetic process from arginine, via ornithine |
| A | 0042176 | biological_process | regulation of protein catabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0001822 | biological_process | kidney development |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004586 | molecular_function | ornithine decarboxylase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006595 | biological_process | polyamine metabolic process |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0009615 | biological_process | response to virus |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0033387 | biological_process | putrescine biosynthetic process from arginine, via ornithine |
| B | 0042176 | biological_process | regulation of protein catabolic process |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 801 |
| Chain | Residue |
| A | SER135 |
| A | GLU136 |
| A | HOH931 |
| B | LYS294 |
| B | ILE295 |
| B | HOH835 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 802 |
| Chain | Residue |
| B | SER135 |
| B | GLU136 |
| B | HOH859 |
| A | LYS294 |
| A | ILE295 |
| A | HOH812 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 803 |
| Chain | Residue |
| A | GLN210 |
| B | GLN418 |
| B | GLN421 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PLP A 600 |
| Chain | Residue |
| A | LYS69 |
| A | ASP88 |
| A | ARG154 |
| A | HIS197 |
| A | SER200 |
| A | GLY236 |
| A | GLY237 |
| A | GLU274 |
| A | GLY276 |
| A | ARG277 |
| A | TYR389 |
| A | XAP601 |
| A | HOH810 |
| A | HOH816 |
| A | HOH819 |
| B | CYS360 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE XAP A 601 |
| Chain | Residue |
| A | CYS164 |
| A | LEU166 |
| A | TYR331 |
| A | ASP332 |
| A | TYR389 |
| A | PLP600 |
| A | HOH842 |
| B | ASP361 |
| B | HOH1018 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE N2P A 700 |
| Chain | Residue |
| A | PRO239 |
| A | GLY240 |
| A | SER241 |
| A | VAL244 |
| A | ARG277 |
| A | ASN385 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PLP B 600 |
| Chain | Residue |
| A | CYS360 |
| B | ALA67 |
| B | LYS69 |
| B | ASP88 |
| B | ARG154 |
| B | HIS197 |
| B | SER200 |
| B | GLY236 |
| B | GLY237 |
| B | GLU274 |
| B | PRO275 |
| B | GLY276 |
| B | ARG277 |
| B | TYR389 |
| B | XAP601 |
| B | HOH808 |
| B | HOH818 |
| B | HOH868 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE XAP B 601 |
| Chain | Residue |
| A | ASP361 |
| B | CYS164 |
| B | LEU166 |
| B | TYR331 |
| B | ASP332 |
| B | TYR389 |
| B | PLP600 |
| B | HOH886 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE N2P B 700 |
| Chain | Residue |
| B | GLY201 |
| B | THR203 |
| B | PRO239 |
| B | VAL244 |
| B | LYS245 |
| B | LEU246 |
| B | HOH913 |
| B | HOH967 |
Functional Information from PROSITE/UniProt
| site_id | PS00878 |
| Number of Residues | 19 |
| Details | ODR_DC_2_1 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. YAvKCNdskaIVktLaatG |
| Chain | Residue | Details |
| A | TYR66-GLY84 |
| site_id | PS00879 |
| Number of Residues | 18 |
| Details | ODR_DC_2_2 Orn/DAP/Arg decarboxylases family 2 signature 2. GaevgfsMyLLDIGGGFP |
| Chain | Residue | Details |
| A | GLY222-PRO239 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor; shared with dimeric partner => ECO:0000305|PubMed:10623504 |
| Chain | Residue | Details |
| A | CYS360 | |
| B | CYS360 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17407445, ECO:0007744|PDB:2OO0 |
| Chain | Residue | Details |
| A | SER200 | |
| A | GLY237 | |
| B | SER200 | |
| B | GLY237 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17407445, ECO:0000269|PubMed:26305948, ECO:0000269|PubMed:26443277, ECO:0007744|PDB:2OO0 |
| Chain | Residue | Details |
| A | GLU274 | |
| A | TYR389 | |
| B | GLU274 | |
| B | TYR389 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:P07805 |
| Chain | Residue | Details |
| A | TYR331 | |
| B | TYR331 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P07805 |
| Chain | Residue | Details |
| A | ASP361 | |
| B | ASP361 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates => ECO:0000250|UniProtKB:P00860 |
| Chain | Residue | Details |
| A | HIS197 | |
| B | HIS197 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:26305948, ECO:0000305|PubMed:17407445 |
| Chain | Residue | Details |
| A | LYS69 | |
| B | LYS69 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000250|UniProtKB:P00860 |
| Chain | Residue | Details |
| A | SER303 | |
| B | SER303 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: S-nitrosocysteine; in inhibited form => ECO:0000305|PubMed:11461922 |
| Chain | Residue | Details |
| A | CYS360 | |
| B | CYS360 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bd0 |
| Chain | Residue | Details |
| A | LYS161 | |
| A | LYS69 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bd0 |
| Chain | Residue | Details |
| B | LYS161 | |
| B | LYS69 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bd0 |
| Chain | Residue | Details |
| A | GLU274 | |
| A | LYS69 | |
| A | HIS197 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bd0 |
| Chain | Residue | Details |
| B | GLU274 | |
| B | LYS69 | |
| B | HIS197 |
