2ONL

Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Mitogen-activated protein kinase 14	polymer	366	41998.9	2	UniProt (Q16539) Pfam (PF00069) In PDB	Homo sapiens (human)	Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
2	C, D	MAP kinase-activated protein kinase 2	polymer	406	46285.5	2	UniProt (P49137) Pfam (PF00069) In PDB	Homo sapiens (human)	MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2

Sequence modifications

A, B: 2 - 360 (UniProt: Q16539)

PDB	External Database	Details
Gly -5	-	cloning artifact
Ser -4	-	cloning artifact
His -3	-	cloning artifact
Met -2	-	cloning artifact
Leu -1	-	cloning artifact
Glu 0	-	cloning artifact
Met 1	-	cloning artifact

C, D: 1 - 400 (UniProt: P49137)

PDB	External Database	Details
Gly -5	-	cloning artifact
Ser -4	-	cloning artifact
His -3	-	cloning artifact
Met -2	-	cloning artifact
Leu -1	-	cloning artifact
Glu 0	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	176568.8
All*	Total formula weight	176568.8

*Water molecules are not included.