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2ONL

Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000165biological_processMAPK cascade
A0000902biological_processcell morphogenesis
A0000922cellular_componentspindle pole
A0001502biological_processcartilage condensation
A0001525biological_processangiogenesis
A0001649biological_processosteoblast differentiation
A0001890biological_processplacenta development
A0002021biological_processresponse to dietary excess
A0002062biological_processchondrocyte differentiation
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004707molecular_functionMAP kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006366biological_processtranscription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006935biological_processchemotaxis
A0006974biological_processDNA damage response
A0007165biological_processsignal transduction
A0007166biological_processcell surface receptor signaling pathway
A0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
A0007519biological_processskeletal muscle tissue development
A0010628biological_processpositive regulation of gene expression
A0010831biological_processpositive regulation of myotube differentiation
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016607cellular_componentnuclear speck
A0018105biological_processpeptidyl-serine phosphorylation
A0019395biological_processfatty acid oxidation
A0019899molecular_functionenzyme binding
A0019903molecular_functionprotein phosphatase binding
A0030168biological_processplatelet activation
A0030278biological_processregulation of ossification
A0030316biological_processosteoclast differentiation
A0031098biological_processstress-activated protein kinase signaling cascade
A0031281biological_processpositive regulation of cyclase activity
A0031663biological_processlipopolysaccharide-mediated signaling pathway
A0032495biological_processresponse to muramyl dipeptide
A0032496biological_processresponse to lipopolysaccharide
A0032735biological_processpositive regulation of interleukin-12 production
A0032868biological_processresponse to insulin
A0033554biological_processcellular response to stress
A0034774cellular_componentsecretory granule lumen
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0035924biological_processcellular response to vascular endothelial growth factor stimulus
A0035994biological_processresponse to muscle stretch
A0038066biological_processp38MAPK cascade
A0042307biological_processpositive regulation of protein import into nucleus
A0042770biological_processsignal transduction in response to DNA damage
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045663biological_processpositive regulation of myoblast differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046323biological_processglucose import
A0046326biological_processpositive regulation of glucose import
A0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0048273molecular_functionmitogen-activated protein kinase p38 binding
A0048863biological_processstem cell differentiation
A0051146biological_processstriated muscle cell differentiation
A0051149biological_processpositive regulation of muscle cell differentiation
A0051403biological_processstress-activated MAPK cascade
A0051525molecular_functionNFAT protein binding
A0060045biological_processpositive regulation of cardiac muscle cell proliferation
A0060348biological_processbone development
A0070935biological_process3'-UTR-mediated mRNA stabilization
A0071222biological_processcellular response to lipopolysaccharide
A0071223biological_processcellular response to lipoteichoic acid
A0071356biological_processcellular response to tumor necrosis factor
A0071479biological_processcellular response to ionizing radiation
A0071493biological_processcellular response to UV-B
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0090336biological_processpositive regulation of brown fat cell differentiation
A0090398biological_processcellular senescence
A0090400biological_processstress-induced premature senescence
A0098586biological_processcellular response to virus
A0098978cellular_componentglutamatergic synapse
A0099179biological_processregulation of synaptic membrane adhesion
A0106310molecular_functionprotein serine kinase activity
A1900015biological_processregulation of cytokine production involved in inflammatory response
A1901741biological_processpositive regulation of myoblast fusion
A1904813cellular_componentficolin-1-rich granule lumen
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0000077biological_processDNA damage checkpoint signaling
B0000165biological_processMAPK cascade
B0000902biological_processcell morphogenesis
B0000922cellular_componentspindle pole
B0001502biological_processcartilage condensation
B0001525biological_processangiogenesis
B0001649biological_processosteoblast differentiation
B0001890biological_processplacenta development
B0002021biological_processresponse to dietary excess
B0002062biological_processchondrocyte differentiation
B0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004707molecular_functionMAP kinase activity
B0004708molecular_functionMAP kinase kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006366biological_processtranscription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006935biological_processchemotaxis
B0006974biological_processDNA damage response
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
B0007519biological_processskeletal muscle tissue development
B0010628biological_processpositive regulation of gene expression
B0010831biological_processpositive regulation of myotube differentiation
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016607cellular_componentnuclear speck
B0018105biological_processpeptidyl-serine phosphorylation
B0019395biological_processfatty acid oxidation
B0019899molecular_functionenzyme binding
B0019903molecular_functionprotein phosphatase binding
B0030168biological_processplatelet activation
B0030278biological_processregulation of ossification
B0030316biological_processosteoclast differentiation
B0031098biological_processstress-activated protein kinase signaling cascade
B0031281biological_processpositive regulation of cyclase activity
B0031663biological_processlipopolysaccharide-mediated signaling pathway
B0032495biological_processresponse to muramyl dipeptide
B0032496biological_processresponse to lipopolysaccharide
B0032735biological_processpositive regulation of interleukin-12 production
B0032868biological_processresponse to insulin
B0033554biological_processcellular response to stress
B0034774cellular_componentsecretory granule lumen
B0035331biological_processnegative regulation of hippo signaling
B0035556biological_processintracellular signal transduction
B0035924biological_processcellular response to vascular endothelial growth factor stimulus
B0035994biological_processresponse to muscle stretch
B0038066biological_processp38MAPK cascade
B0042307biological_processpositive regulation of protein import into nucleus
B0042770biological_processsignal transduction in response to DNA damage
B0043536biological_processpositive regulation of blood vessel endothelial cell migration
B0045648biological_processpositive regulation of erythrocyte differentiation
B0045663biological_processpositive regulation of myoblast differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046323biological_processglucose import
B0046326biological_processpositive regulation of glucose import
B0048010biological_processvascular endothelial growth factor receptor signaling pathway
B0048273molecular_functionmitogen-activated protein kinase p38 binding
B0048863biological_processstem cell differentiation
B0051146biological_processstriated muscle cell differentiation
B0051149biological_processpositive regulation of muscle cell differentiation
B0051403biological_processstress-activated MAPK cascade
B0051525molecular_functionNFAT protein binding
B0060045biological_processpositive regulation of cardiac muscle cell proliferation
B0060348biological_processbone development
B0070935biological_process3'-UTR-mediated mRNA stabilization
B0071222biological_processcellular response to lipopolysaccharide
B0071223biological_processcellular response to lipoteichoic acid
B0071356biological_processcellular response to tumor necrosis factor
B0071479biological_processcellular response to ionizing radiation
B0071493biological_processcellular response to UV-B
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090336biological_processpositive regulation of brown fat cell differentiation
B0090398biological_processcellular senescence
B0090400biological_processstress-induced premature senescence
B0098586biological_processcellular response to virus
B0098978cellular_componentglutamatergic synapse
B0099179biological_processregulation of synaptic membrane adhesion
B0106310molecular_functionprotein serine kinase activity
B1900015biological_processregulation of cytokine production involved in inflammatory response
B1901741biological_processpositive regulation of myoblast fusion
B1904813cellular_componentficolin-1-rich granule lumen
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0000165biological_processMAPK cascade
C0002224biological_processtoll-like receptor signaling pathway
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004683molecular_functioncalmodulin-dependent protein kinase activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0006338biological_processchromatin remodeling
C0006468biological_processprotein phosphorylation
C0006691biological_processleukotriene metabolic process
C0006954biological_processinflammatory response
C0006974biological_processDNA damage response
C0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
C0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
C0016310biological_processphosphorylation
C0018105biological_processpeptidyl-serine phosphorylation
C0032496biological_processresponse to lipopolysaccharide
C0032675biological_processregulation of interleukin-6 production
C0032680biological_processregulation of tumor necrosis factor production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0034097biological_processresponse to cytokine
C0035556biological_processintracellular signal transduction
C0035924biological_processcellular response to vascular endothelial growth factor stimulus
C0038066biological_processp38MAPK cascade
C0043488biological_processregulation of mRNA stability
C0044024molecular_functionhistone H2AS1 kinase activity
C0044351biological_processmacropinocytosis
C0048010biological_processvascular endothelial growth factor receptor signaling pathway
C0048255biological_processmRNA stabilization
C0048839biological_processinner ear development
C0051019molecular_functionmitogen-activated protein kinase binding
C0060907biological_processpositive regulation of macrophage cytokine production
C0070062cellular_componentextracellular exosome
C0070935biological_process3'-UTR-mediated mRNA stabilization
C0106310molecular_functionprotein serine kinase activity
C1900034biological_processregulation of cellular response to heat
D0000165biological_processMAPK cascade
D0002224biological_processtoll-like receptor signaling pathway
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004683molecular_functioncalmodulin-dependent protein kinase activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006338biological_processchromatin remodeling
D0006468biological_processprotein phosphorylation
D0006691biological_processleukotriene metabolic process
D0006954biological_processinflammatory response
D0006974biological_processDNA damage response
D0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
D0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
D0016310biological_processphosphorylation
D0018105biological_processpeptidyl-serine phosphorylation
D0032496biological_processresponse to lipopolysaccharide
D0032675biological_processregulation of interleukin-6 production
D0032680biological_processregulation of tumor necrosis factor production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0034097biological_processresponse to cytokine
D0035556biological_processintracellular signal transduction
D0035924biological_processcellular response to vascular endothelial growth factor stimulus
D0038066biological_processp38MAPK cascade
D0043488biological_processregulation of mRNA stability
D0044024molecular_functionhistone H2AS1 kinase activity
D0044351biological_processmacropinocytosis
D0048010biological_processvascular endothelial growth factor receptor signaling pathway
D0048255biological_processmRNA stabilization
D0048839biological_processinner ear development
D0051019molecular_functionmitogen-activated protein kinase binding
D0060907biological_processpositive regulation of macrophage cytokine production
D0070062cellular_componentextracellular exosome
D0070935biological_process3'-UTR-mediated mRNA stabilization
D0106310molecular_functionprotein serine kinase activity
D1900034biological_processregulation of cellular response to heat
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK
ChainResidueDetails
AVAL30-LYS54
CLEU70-LYS93

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY
ChainResidueDetails
CILE182-TYR194

site_idPS01351
Number of Residues104
DetailsMAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC
ChainResidueDetails
APHE59-CYS162

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
CASP186
DASP186

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
CLEU70
CLYS93
DLEU70
DLYS93

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING:
ChainResidueDetails
CGLU139
DGLU139

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:8846784
ChainResidueDetails
CSER9
DSER9

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:8846784
ChainResidueDetails
CTHR25
DTHR25
BLYS54
BPRO153

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784
ChainResidueDetails
CTHR222
DTHR222

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784
ChainResidueDetails
CSER272
DSER272

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000250
ChainResidueDetails
CSER328
DSER328

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CTHR334
DTHR334

site_idSWS_FT_FI10
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:21131586
ChainResidueDetails
CLYS353
DLYS353

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
ASER154
AASP150

site_idCSA10
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BLYS152
BTHR185
BASP150

site_idCSA11
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CTHR226
CASP186
CLYS188

site_idCSA12
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DTHR226
DASP186
DLYS188

site_idCSA13
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASN155
ALYS152
AASP150

site_idCSA14
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASN155
BLYS152
BASP150

site_idCSA15
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP186
CASN191
CLYS188

site_idCSA16
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP186
DASN191
DLYS188

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BSER154
BASP150

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP186
CGLU190

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP186
DGLU190

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
ALYS152
AASP150

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BLYS152
BASP150

site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
CASP186
CLYS188

site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
DASP186
DLYS188

site_idCSA9
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
ALYS152
ATHR185
AASP150

224572

PDB entries from 2024-09-04

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