2OD7

Crystal Structure of yHst2 bound to the intermediate analogue ADP-HPD, and and aceylated H4 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	NAD-dependent deacetylase HST2	polymer	308	34794.8	1	UniProt (P53686) Pfam (PF02146) In PDB	Saccharomyces cerevisiae (baker's yeast)	Homologous to SIR2 protein 2
2	B	Acetylated histone H4 peptide	polymer	14	1610.9	1
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE	non-polymer		542.3	1	Chemie (A1R)
5		water	water		18.0	133	Chemie (HOH)

Sequence modifications

A: 1 - 294 (UniProt: P53686)

PDB	External Database	Details
Met -13	-	initiating methionine
Arg -12	-	cloning artifact
Gly -11	-	cloning artifact
Ser -10	-	cloning artifact
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	cloning artifact
Met -2	-	cloning artifact
Ala -1	-	cloning artifact
Ser 0	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36405.8
Non-Polymers*	Number of molecules	2
	Total formula weight	607.7
All*	Total formula weight	37013.5

*Water molecules are not included.