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2OBO

Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, CHCV NS3 proteasepolymer20021233.22UniProt (Q91RS4)
Pfam (PF02907)
In PDB
Hepatitis C virus
2B, DHCV NS4A peptidepolymer232394.02UniProt (Q9QP06)
Pfam (PF01006)
In PDB
Hepatitis C virus
3A, CZINC IONnon-polymer65.42Chemie (ZN)
4ABETA-MERCAPTOETHANOLnon-polymer78.11Chemie (BME)
5Atert-butyl {(2S)-1-[(1R,2S,5S)-2-{[(2S,3R)-4-amino-1-cyclopropyl-3-hydroxy-4-oxobutan-2-yl]carbamoyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hex-3-yl]-3,3-dimethyl-1-oxobutan-2-yl}carbamatenon-polymer508.71BIRD (PRD_000958)
Chemie (HUD)
6waterwater18.0135Chemie (HOH)
Sequence modifications
A, C: 1 - 181 (UniProt: Q91RS4)
PDBExternal DatabaseDetails
Met -10-expression tag
Ala -9-expression tag
Ser -8-expression tag
Met -7-expression tag
Thr -6-expression tag
Gly -5-expression tag
Gly -4-expression tag
Gln -3-expression tag
Gln -2-expression tag
Met -1-expression tag
Gly 0-expression tag
Thr 40Ala 40conflict
Ser 91Ala 91conflict
Gly 182-expression tag
Ser 183-expression tag
His 184-expression tag
His 185-expression tag
His 186-expression tag
His 187-expression tag
His 188-expression tag
His 189-expression tag
B, D: 21 - 39 (UniProt: Q9QP06)
PDBExternal DatabaseDetails
Lys 19-expression tag
Lys 20-expression tag
Lys 40-expression tag
Lys 41-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight47254.5
Non-Polymers*Number of molecules4
Total formula weight717.6
All*Total formula weight47972.1
*Water molecules are not included.

217705

PDB entries from 2024-03-27

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