2OBO
Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0019087 | biological_process | transformation of host cell by virus |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0044423 | cellular_component | virion component |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0097264 | biological_process | self proteolysis |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016020 | cellular_component | membrane |
| C | 0019062 | biological_process | virion attachment to host cell |
| C | 0019087 | biological_process | transformation of host cell by virus |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0044423 | cellular_component | virion component |
| C | 0046718 | biological_process | symbiont entry into host cell |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0097264 | biological_process | self proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 901 |
| Chain | Residue |
| A | CYS97 |
| A | THR98 |
| A | CYS99 |
| A | CYS145 |
| A | HOH1000 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME A 902 |
| Chain | Residue |
| A | LEU13 |
| A | CYS16 |
| A | ILE17 |
| A | THR38 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HUD A 903 |
| Chain | Residue |
| A | GLN41 |
| A | HIS57 |
| A | LYS136 |
| A | GLY137 |
| A | SER138 |
| A | SER139 |
| A | ARG155 |
| A | ALA156 |
| A | ALA157 |
| A | ASP168 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 201 |
| Chain | Residue |
| C | CYS97 |
| C | CYS99 |
| C | CYS145 |
| C | HOH301 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rgq |
| Chain | Residue | Details |
| A | ASP81 | |
| A | SER139 | |
| A | GLY137 | |
| A | HIS57 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rgq |
| Chain | Residue | Details |
| C | ASP81 | |
| C | SER139 | |
| C | GLY137 | |
| C | HIS57 |
