2OBO

Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	transformation of host cell by virus
A	0033644	cellular_component	host cell membrane
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
A	0097264	biological_process	self proteolysis
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0019062	biological_process	virion attachment to host cell
C	0019087	biological_process	transformation of host cell by virus
C	0033644	cellular_component	host cell membrane
C	0044423	cellular_component	virion component
C	0046718	biological_process	symbiont entry into host cell
C	0046872	molecular_function	metal ion binding
C	0097264	biological_process	self proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 901

Chain	Residue
A	CYS97
A	THR98
A	CYS99
A	CYS145
A	HOH1000

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 902

Chain	Residue
A	LEU13
A	CYS16
A	ILE17
A	THR38

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site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE HUD A 903

Chain	Residue
A	GLN41
A	HIS57
A	LYS136
A	GLY137
A	SER138
A	SER139
A	ARG155
A	ALA156
A	ALA157
A	ASP168

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 201

Chain	Residue
C	CYS97
C	CYS99
C	CYS145
C	HOH301

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