2O2K
Crystal Structure of the Activation Domain of Human Methionine Synthase Isoform/Mutant D963E/K1071N
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Methionine synthase | polymer | 355 | 40527.7 | 2 | UniProt (Q99707) Pfam (PF02965) In PDB | Homo sapiens (human) | 5-methyltetrahydrofolate--homocysteine methyltransferase, Methionine synthase, vitamin-B12 dependent, MS |
2 | water | water | 18.0 | 1195 | Chemie (HOH) |
Sequence modifications
A, B: 925 - 1265 (UniProt: Q99707)
PDB | External Database | Details |
---|---|---|
Met 924 | - | initiating methionine |
Glu 963 | Asp 963 | SEE REMARK 999 |
Asn 1071 | Lys 1071 | SEE REMARK 999 |
Lys 1266 | - | expression tag |
Leu 1267 | - | expression tag |
Ala 1268 | - | expression tag |
Ala 1269 | - | expression tag |
Ala 1270 | - | expression tag |
Leu 1271 | - | expression tag |
Glu 1272 | - | expression tag |
His 1273 | - | expression tag |
His 1274 | - | expression tag |
His 1275 | - | expression tag |
His 1276 | - | expression tag |
His 1277 | - | expression tag |
His 1278 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 81055.4 | |
All* | Total formula weight | 81055.4 |