2O2K

Crystal Structure of the Activation Domain of Human Methionine Synthase Isoform/Mutant D963E/K1071N

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Methionine synthase	polymer	355	40527.7	2	UniProt (Q99707) Pfam (PF02965)	Homo sapiens (human)	5-methyltetrahydrofolate--homocysteine methyltransferase, Methionine synthase, vitamin-B12 dependent, MS
2	C, D (A, B)	water	water		18.0	1195	Chemie (HOH)

Sequence modifications

A, B: 925 - 1265 (UniProt: Q99707)

PDB	External Database	Details
Met 924	-	initiating methionine
Glu 963	Asp 963	SEE REMARK 999
Asn 1071	Lys 1071	SEE REMARK 999
Lys 1266	-	expression tag
Leu 1267	-	expression tag
Ala 1268	-	expression tag
Ala 1269	-	expression tag
Ala 1270	-	expression tag
Leu 1271	-	expression tag
Glu 1272	-	expression tag
His 1273	-	expression tag
His 1274	-	expression tag
His 1275	-	expression tag
His 1276	-	expression tag
His 1277	-	expression tag
His 1278	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	81055.4
All*	Total formula weight	81055.4

*Water molecules are not included.