2NQD
Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin L
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chagasin | polymer | 109 | 11923.3 | 1 | UniProt (Q966X9) Pfam (PF09394) | Trypanosoma cruzi | cysteine protease inhibitor |
| 2 | B (B) | Cathepsin L | polymer | 221 | 24288.8 | 1 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (human) | cysteine protease, Major excreted protein, MEP |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 564 | Chemie (HOH) |
Sequence modifications
B: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 25 | Cys 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36212.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 58.4 | |
| All* | Total formula weight | 36694.9 |
