2NQD

Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin L

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0009986	cellular_component	cell surface
A	0020016	cellular_component	ciliary pocket
A	0031410	cellular_component	cytoplasmic vesicle
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG

Chain	Residue	Details
B	MET161-GLY171

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site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM

Chain	Residue	Details
B	TYR182-MET201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:9468501

Chain	Residue	Details
B	ALA25

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
B	HIS163
B	ASN187

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:9468501

Chain	Residue	Details
B	GLU1

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218

Chain	Residue	Details
B	ASN108

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 9pap

Chain	Residue	Details
B	ASN187
B	GLN19
B	HIS163

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