2MPZ

Atomic model of the Abeta D23N "Iowa" mutant using solid-state NMR, EM and Rosetta modeling

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, AA, B, C, D... (A, B, C, D, E...)	Amyloid beta A4 protein	polymer	26	2650.1	27	UniProt (P05067) Pfam (PF03494)	Homo sapiens (human)	ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a: 15 - 40 (UniProt: P05067)

PDB	External Database	Details
Asn 23	Asp 694	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	27
	Total formula weight	71553.9
All*	Total formula weight	71553.9

*Water molecules are not included.