2J59

Crystal structure of the ARF1:ARHGAP21-ArfBD complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	ADP-RIBOSYLATION FACTOR 1	polymer	166	18951.6	6	UniProt (P84078) Pfam (PF00025)	MUS MUSCULUS (MOUSE)	ARF1
2	G, H, I, J, K... (M, N, O, P, Q...)	RHO-GTPASE ACTIVATING PROTEIN 10	polymer	168	19378.9	6	UniProt (Q8NI19) Pfam (PF00169) UniProt (by SIFTS) (Q5T5U3)	HOMO SAPIENS (HUMAN)	RHOGAP PROTEIN, ARHGAP21
3	AA, M, P, S, V... (F, A, B, C, D...)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	6	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)
4	BA, N, Q, T, W... (F, A, B, C, D...)	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG) PubChem (888)
5	CA, O, R (F, A, B)	1,4-DIETHYLENE DIOXIDE	non-polymer		88.1	3	Chemie (DIO)
6	GA, U, Z (O, C, E)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
7	DA, EA, FA, HA, IA... (M, N, O, P, Q...)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
8	KA, LA, MA, NA, OA... (A, B, C, D, E...)	water	water		18.0	1656	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 16 - 17 (PDB: 2J59)
A, B, C, D, E, F: 18 - 181 (UniProt: P84078)

PDB	External Database	Details
Leu 71	Gln 70	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	229983.2
Non-Polymers*	Number of molecules	24
	Total formula weight	4311.8
All*	Total formula weight	234295.0

*Water molecules are not included.