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2J59

Crystal structure of the ARF1:ARHGAP21-ArfBD complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000287molecular_functionmagnesium ion binding
A0002090biological_processregulation of receptor internalization
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005770cellular_componentlate endosome
A0005778cellular_componentperoxisomal membrane
A0005794cellular_componentGolgi apparatus
A0005802cellular_componenttrans-Golgi network
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006878biological_processintracellular copper ion homeostasis
A0006886biological_processintracellular protein transport
A0007015biological_processactin filament organization
A0012505cellular_componentendomembrane system
A0014069cellular_componentpostsynaptic density
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019904molecular_functionprotein domain specific binding
A0030017cellular_componentsarcomere
A0030137cellular_componentCOPI-coated vesicle
A0031252cellular_componentcell leading edge
A0032991cellular_componentprotein-containing complex
A0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
A0034379biological_processvery-low-density lipoprotein particle assembly
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0045807biological_processpositive regulation of endocytosis
A0045956biological_processpositive regulation of calcium ion-dependent exocytosis
A0050714biological_processpositive regulation of protein secretion
A0055108biological_processGolgi to transport vesicle transport
A0060292biological_processlong-term synaptic depression
A0060999biological_processpositive regulation of dendritic spine development
A0070142biological_processsynaptic vesicle budding
A0097061biological_processdendritic spine organization
A0097212biological_processlysosomal membrane organization
A0098586biological_processcellular response to virus
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0098978cellular_componentglutamatergic synapse
A1902307biological_processpositive regulation of sodium ion transmembrane transport
A1902824biological_processpositive regulation of late endosome to lysosome transport
A1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
A1903725biological_processregulation of phospholipid metabolic process
A1990386biological_processmitotic cleavage furrow ingression
A1990583molecular_functionphospholipase D activator activity
B0000139cellular_componentGolgi membrane
B0000287molecular_functionmagnesium ion binding
B0002090biological_processregulation of receptor internalization
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005770cellular_componentlate endosome
B0005778cellular_componentperoxisomal membrane
B0005794cellular_componentGolgi apparatus
B0005802cellular_componenttrans-Golgi network
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006878biological_processintracellular copper ion homeostasis
B0006886biological_processintracellular protein transport
B0007015biological_processactin filament organization
B0012505cellular_componentendomembrane system
B0014069cellular_componentpostsynaptic density
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016192biological_processvesicle-mediated transport
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0019904molecular_functionprotein domain specific binding
B0030017cellular_componentsarcomere
B0030137cellular_componentCOPI-coated vesicle
B0031252cellular_componentcell leading edge
B0032991cellular_componentprotein-containing complex
B0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
B0034379biological_processvery-low-density lipoprotein particle assembly
B0043005cellular_componentneuron projection
B0045202cellular_componentsynapse
B0045807biological_processpositive regulation of endocytosis
B0045956biological_processpositive regulation of calcium ion-dependent exocytosis
B0050714biological_processpositive regulation of protein secretion
B0055108biological_processGolgi to transport vesicle transport
B0060292biological_processlong-term synaptic depression
B0060999biological_processpositive regulation of dendritic spine development
B0070142biological_processsynaptic vesicle budding
B0097061biological_processdendritic spine organization
B0097212biological_processlysosomal membrane organization
B0098586biological_processcellular response to virus
B0098974biological_processpostsynaptic actin cytoskeleton organization
B0098978cellular_componentglutamatergic synapse
B1902307biological_processpositive regulation of sodium ion transmembrane transport
B1902824biological_processpositive regulation of late endosome to lysosome transport
B1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
B1903725biological_processregulation of phospholipid metabolic process
B1990386biological_processmitotic cleavage furrow ingression
B1990583molecular_functionphospholipase D activator activity
C0000139cellular_componentGolgi membrane
C0000287molecular_functionmagnesium ion binding
C0002090biological_processregulation of receptor internalization
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005770cellular_componentlate endosome
C0005778cellular_componentperoxisomal membrane
C0005794cellular_componentGolgi apparatus
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006878biological_processintracellular copper ion homeostasis
C0006886biological_processintracellular protein transport
C0007015biological_processactin filament organization
C0012505cellular_componentendomembrane system
C0014069cellular_componentpostsynaptic density
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0016192biological_processvesicle-mediated transport
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0019904molecular_functionprotein domain specific binding
C0030017cellular_componentsarcomere
C0030137cellular_componentCOPI-coated vesicle
C0031252cellular_componentcell leading edge
C0032991cellular_componentprotein-containing complex
C0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
C0034379biological_processvery-low-density lipoprotein particle assembly
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0045807biological_processpositive regulation of endocytosis
C0045956biological_processpositive regulation of calcium ion-dependent exocytosis
C0050714biological_processpositive regulation of protein secretion
C0055108biological_processGolgi to transport vesicle transport
C0060292biological_processlong-term synaptic depression
C0060999biological_processpositive regulation of dendritic spine development
C0070142biological_processsynaptic vesicle budding
C0097061biological_processdendritic spine organization
C0097212biological_processlysosomal membrane organization
C0098586biological_processcellular response to virus
C0098974biological_processpostsynaptic actin cytoskeleton organization
C0098978cellular_componentglutamatergic synapse
C1902307biological_processpositive regulation of sodium ion transmembrane transport
C1902824biological_processpositive regulation of late endosome to lysosome transport
C1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
C1903725biological_processregulation of phospholipid metabolic process
C1990386biological_processmitotic cleavage furrow ingression
C1990583molecular_functionphospholipase D activator activity
D0000139cellular_componentGolgi membrane
D0000287molecular_functionmagnesium ion binding
D0002090biological_processregulation of receptor internalization
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005770cellular_componentlate endosome
D0005778cellular_componentperoxisomal membrane
D0005794cellular_componentGolgi apparatus
D0005802cellular_componenttrans-Golgi network
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006878biological_processintracellular copper ion homeostasis
D0006886biological_processintracellular protein transport
D0007015biological_processactin filament organization
D0012505cellular_componentendomembrane system
D0014069cellular_componentpostsynaptic density
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0016192biological_processvesicle-mediated transport
D0016787molecular_functionhydrolase activity
D0019003molecular_functionGDP binding
D0019904molecular_functionprotein domain specific binding
D0030017cellular_componentsarcomere
D0030137cellular_componentCOPI-coated vesicle
D0031252cellular_componentcell leading edge
D0032991cellular_componentprotein-containing complex
D0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
D0034379biological_processvery-low-density lipoprotein particle assembly
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0045807biological_processpositive regulation of endocytosis
D0045956biological_processpositive regulation of calcium ion-dependent exocytosis
D0050714biological_processpositive regulation of protein secretion
D0055108biological_processGolgi to transport vesicle transport
D0060292biological_processlong-term synaptic depression
D0060999biological_processpositive regulation of dendritic spine development
D0070142biological_processsynaptic vesicle budding
D0097061biological_processdendritic spine organization
D0097212biological_processlysosomal membrane organization
D0098586biological_processcellular response to virus
D0098974biological_processpostsynaptic actin cytoskeleton organization
D0098978cellular_componentglutamatergic synapse
D1902307biological_processpositive regulation of sodium ion transmembrane transport
D1902824biological_processpositive regulation of late endosome to lysosome transport
D1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
D1903725biological_processregulation of phospholipid metabolic process
D1990386biological_processmitotic cleavage furrow ingression
D1990583molecular_functionphospholipase D activator activity
E0000139cellular_componentGolgi membrane
E0000287molecular_functionmagnesium ion binding
E0002090biological_processregulation of receptor internalization
E0003924molecular_functionGTPase activity
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005770cellular_componentlate endosome
E0005778cellular_componentperoxisomal membrane
E0005794cellular_componentGolgi apparatus
E0005802cellular_componenttrans-Golgi network
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006878biological_processintracellular copper ion homeostasis
E0006886biological_processintracellular protein transport
E0007015biological_processactin filament organization
E0012505cellular_componentendomembrane system
E0014069cellular_componentpostsynaptic density
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0016192biological_processvesicle-mediated transport
E0016787molecular_functionhydrolase activity
E0019003molecular_functionGDP binding
E0019904molecular_functionprotein domain specific binding
E0030017cellular_componentsarcomere
E0030137cellular_componentCOPI-coated vesicle
E0031252cellular_componentcell leading edge
E0032991cellular_componentprotein-containing complex
E0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
E0034379biological_processvery-low-density lipoprotein particle assembly
E0043005cellular_componentneuron projection
E0045202cellular_componentsynapse
E0045807biological_processpositive regulation of endocytosis
E0045956biological_processpositive regulation of calcium ion-dependent exocytosis
E0050714biological_processpositive regulation of protein secretion
E0055108biological_processGolgi to transport vesicle transport
E0060292biological_processlong-term synaptic depression
E0060999biological_processpositive regulation of dendritic spine development
E0070142biological_processsynaptic vesicle budding
E0097061biological_processdendritic spine organization
E0097212biological_processlysosomal membrane organization
E0098586biological_processcellular response to virus
E0098974biological_processpostsynaptic actin cytoskeleton organization
E0098978cellular_componentglutamatergic synapse
E1902307biological_processpositive regulation of sodium ion transmembrane transport
E1902824biological_processpositive regulation of late endosome to lysosome transport
E1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
E1903725biological_processregulation of phospholipid metabolic process
E1990386biological_processmitotic cleavage furrow ingression
E1990583molecular_functionphospholipase D activator activity
F0000139cellular_componentGolgi membrane
F0000287molecular_functionmagnesium ion binding
F0002090biological_processregulation of receptor internalization
F0003924molecular_functionGTPase activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005770cellular_componentlate endosome
F0005778cellular_componentperoxisomal membrane
F0005794cellular_componentGolgi apparatus
F0005802cellular_componenttrans-Golgi network
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006878biological_processintracellular copper ion homeostasis
F0006886biological_processintracellular protein transport
F0007015biological_processactin filament organization
F0012505cellular_componentendomembrane system
F0014069cellular_componentpostsynaptic density
F0015031biological_processprotein transport
F0016020cellular_componentmembrane
F0016192biological_processvesicle-mediated transport
F0016787molecular_functionhydrolase activity
F0019003molecular_functionGDP binding
F0019904molecular_functionprotein domain specific binding
F0030017cellular_componentsarcomere
F0030137cellular_componentCOPI-coated vesicle
F0031252cellular_componentcell leading edge
F0032991cellular_componentprotein-containing complex
F0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
F0034379biological_processvery-low-density lipoprotein particle assembly
F0043005cellular_componentneuron projection
F0045202cellular_componentsynapse
F0045807biological_processpositive regulation of endocytosis
F0045956biological_processpositive regulation of calcium ion-dependent exocytosis
F0050714biological_processpositive regulation of protein secretion
F0055108biological_processGolgi to transport vesicle transport
F0060292biological_processlong-term synaptic depression
F0060999biological_processpositive regulation of dendritic spine development
F0070142biological_processsynaptic vesicle budding
F0097061biological_processdendritic spine organization
F0097212biological_processlysosomal membrane organization
F0098586biological_processcellular response to virus
F0098974biological_processpostsynaptic actin cytoskeleton organization
F0098978cellular_componentglutamatergic synapse
F1902307biological_processpositive regulation of sodium ion transmembrane transport
F1902824biological_processpositive regulation of late endosome to lysosome transport
F1902953biological_processpositive regulation of ER to Golgi vesicle-mediated transport
F1903725biological_processregulation of phospholipid metabolic process
F1990386biological_processmitotic cleavage furrow ingression
F1990583molecular_functionphospholipase D activator activity
M0005543molecular_functionphospholipid binding
N0005543molecular_functionphospholipid binding
O0005543molecular_functionphospholipid binding
P0005543molecular_functionphospholipid binding
Q0005543molecular_functionphospholipid binding
R0005543molecular_functionphospholipid binding
Functional Information from PDB Data
site_idAC1
Number of Residues27
DetailsBINDING SITE FOR RESIDUE GTP A1181
ChainResidue
AASP26
ATHR48
AGLY69
AGLY70
AASN126
ALYS127
AASP129
ALEU130
ACYS159
AALA160
AMG1182
AALA27
AHOH3031
AHOH3044
AHOH3074
AHOH3184
AHOH3185
AHOH3186
AHOH3187
AHOH3188
AALA28
AGLY29
ALYS30
ATHR31
ATHR32
ATHR45
APRO47

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A1182
ChainResidue
ATHR31
ATHR48
AGTP1181
AHOH3074
AHOH3188

site_idAC3
Number of Residues27
DetailsBINDING SITE FOR RESIDUE GTP B1181
ChainResidue
BASP26
BALA27
BALA28
BGLY29
BLYS30
BTHR31
BTHR32
BTHR45
BPRO47
BTHR48
BGLY69
BGLY70
BASN126
BLYS127
BASP129
BLEU130
BCYS159
BALA160
BMG1182
BHOH3025
BHOH3031
BHOH3033
BHOH3064
BHOH3176
BHOH3177
BHOH3178
BHOH3179

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B1182
ChainResidue
BTHR31
BTHR48
BGTP1181
BHOH3033
BHOH3064

site_idAC5
Number of Residues27
DetailsBINDING SITE FOR RESIDUE GTP C1181
ChainResidue
CASP26
CALA27
CALA28
CGLY29
CLYS30
CTHR31
CTHR32
CTHR45
CTHR48
CGLY69
CGLY70
CASN126
CLYS127
CASP129
CLEU130
CCYS159
CALA160
CMG1182
CHOH3018
CHOH3036
CHOH3060
CHOH3173
CHOH3174
CHOH3175
CHOH3176
CHOH3177
CHOH3178

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG C1182
ChainResidue
CTHR31
CTHR48
CGTP1181
CHOH3036
CHOH3060

site_idAC7
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GTP D1181
ChainResidue
DGLY29
DLYS30
DTHR31
DTHR32
DTHR45
DTHR48
DGLY69
DGLY70
DASN126
DLYS127
DASP129
DLEU130
DCYS159
DALA160
DMG1182
DHOH3035
DHOH3063
DHOH3172
DHOH3174
DHOH3175
DHOH3176
DHOH3177
DASP26
DALA27
DALA28

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D1182
ChainResidue
DTHR31
DTHR48
DGTP1181
DHOH3035
DHOH3063

site_idAC9
Number of Residues29
DetailsBINDING SITE FOR RESIDUE GTP E1181
ChainResidue
EASP26
EALA27
EALA28
EGLY29
ELYS30
ETHR31
ETHR32
ETHR45
EPRO47
ETHR48
EGLY69
EGLY70
EASN126
ELYS127
EASP129
ELEU130
ECYS159
EALA160
EMG1182
EHOH3029
EHOH3038
EHOH3076
EHOH3190
EHOH3191
EHOH3192
EHOH3193
EHOH3194
EHOH3195
EHOH3196

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG E1182
ChainResidue
ETHR31
ETHR48
EGTP1181
EHOH3038
EHOH3076

site_idBC2
Number of Residues26
DetailsBINDING SITE FOR RESIDUE GTP F1181
ChainResidue
FASP26
FALA27
FALA28
FGLY29
FLYS30
FTHR31
FTHR32
FTHR45
FPRO47
FTHR48
FGLY69
FGLY70
FASN126
FLYS127
FASP129
FLEU130
FCYS159
FALA160
FMG1182
FHOH3027
FHOH3059
FHOH3156
FHOH3157
FHOH3158
FHOH3161
FHOH3162

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG F1182
ChainResidue
FTHR31
FTHR48
FGTP1181
FHOH3059
FHOH3157

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 M2064
ChainResidue
MARG940
MTRP957
MTHR1002
MLYS1003
MHOH3120

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 N2064
ChainResidue
NARG940
NTRP957
NTHR1002
NLYS1003
NHOH3103

site_idBC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 O2062
ChainResidue
OARG940
OTRP957
OTHR1002
OLYS1003
OHOH3075

site_idBC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 P2064
ChainResidue
PARG940
PTRP957
PTHR1002
PLYS1003
PHOH3093

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 Q2064
ChainResidue
QARG940
QTRP957
QTHR1002
QLYS1003

site_idBC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 R2064
ChainResidue
RARG940
RTRP957
RTHR1002
RLYS1003
RHOH3077

site_idCC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE DIO A1183
ChainResidue
ATRP153
ATYR154
AILE155
DTRP153
DTYR154
DILE155

site_idCC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DIO B1183
ChainResidue
BTRP153
BTYR154
BILE155
ETYR154
EILE155

site_idCC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DIO F1183
ChainResidue
CTRP153
CTYR154
CILE155
FTYR154
FILE155

site_idCC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO C1183
ChainResidue
CARG75
CPRO76
CGLU106
CARG109
CHOH3179

site_idCC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO O2063
ChainResidue
BLYS36
BGLY163
BHOH3018
OGLN959
OHOH3076

site_idCC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO E1183
ChainResidue
EGLN86
EASP118
EGLN176
EGLN180

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
MILE954
ELYS127
FLEU25
FLYS127
NILE954
OILE954
PILE954
QILE954
RILE954
DLEU25
DLYS127
ELEU25

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0007744|PDB:1O3Y, ECO:0007744|PDB:2J59
ChainResidueDetails
ATHR161
BTHR161
CTHR161
DTHR161
ETHR161
FTHR161

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
ALEU71

site_idCSA10
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DALA27

site_idCSA11
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
EALA27

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BLEU71

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CLEU71

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DLEU71

site_idCSA5
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
ELEU71

site_idCSA6
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
FLEU71

site_idCSA7
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AALA27

site_idCSA8
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BALA27

site_idCSA9
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CALA27

222036

PDB entries from 2024-07-03

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