2IW5
Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 | polymer | 666 | 74126.8 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | HOMO SAPIENS (HUMAN) | AMINE OXIDASE FLAVIN-CONTAINING DOMAIN PROTEIN 2, BRAF35-HDAC COMPLEX PROTEIN BHC110 |
| 2 | B (B) | REST COREPRESSOR 1 | polymer | 235 | 26425.7 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | HOMO SAPIENS (HUMAN) | PROTEIN COREST |
| 3 | C (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 4 | D, G, I (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | E, F (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | H (A) | AMMONIUM ION | non-polymer | 18.0 | 1 | Chemie (NH4) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 100552.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1094.1 | |
| All* | Total formula weight | 101646.6 |
