2IK8
Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Guanine nucleotide-binding protein G(i), alpha-1 subunit | polymer | 324 | 37102.3 | 2 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B, D (B, D) | Regulator of G-protein signaling 16 | polymer | 140 | 15917.9 | 2 | UniProt (O15492) Pfam (PF00615) | Homo sapiens (human) | RGS16, Retinally abundant regulator of G-protein signaling, RGS-R, A28-RGS14P |
| 3 | E, M (A, C) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) PubChem (5311325) | |||
| 4 | F, N (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | G, H, I, J, L... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 6 | K, Q (A, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 7 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
B, D: 53 - 190 (UniProt: O15492)
| PDB | External Database | Details |
|---|---|---|
| Ser 51 | - | cloning artifact |
| Met 52 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 106040.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1909.5 | |
| All* | Total formula weight | 107949.8 |
