2HL5
Crystal structure of the C-terminal domain of human EB1 in complex with the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Microtubule-associated protein RP/EB family member 1 | polymer | 80 | 9212.0 | 2 | UniProt (Q15691) Pfam (PF03271) | Homo sapiens (human) | APC-binding protein EB1, End-binding protein 1, EB1 |
| 2 | B, D (C, D) | Dynactin-1 | polymer | 97 | 10369.5 | 2 | UniProt (Q14203) Pfam (PF01302) | Homo sapiens (human) | 150 kDa dynein-associated polypeptide, DP-150, DAP-150, p150-glued, p135 |
| 3 | E (D) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | F, G, H, I (A, C, B, D) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A, B: 191 - 268 (UniProt: Q15691)
C, D: 18 - 111 (UniProt: Q14203)
| PDB | External Database | Details |
|---|---|---|
| Gly 189 | - | cloning artifact |
| Ser 190 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 15 | - | cloning artifact |
| Ser 16 | - | cloning artifact |
| His 17 | - | cloning artifact |
| Met 49 | Ala 49 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 39163.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 39198.6 |
