2HE4
The crystal structure of the second PDZ domain of human NHERF-2 (SLC9A3R2) interacting with a mode 1 PDZ binding motif
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | polymer | 90 | 9931.3 | 1 | UniProt (Q15599) Pfam (PF00595) | Homo sapiens (human) | NHERF-2, Tyrosine kinase activator protein 1, TKA-1, SRY-interacting protein 1, SIP- 1, Solute carrier family 9 isoform A3 regulatory factor 2, NHE3 kinase A regulatory protein E3KARP, Sodium-hydrogen exchanger regulatory factor 2 |
| 2 | B (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | C (A) | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A: 147 - 230 (UniProt: Q15599)
| PDB | External Database | Details |
|---|---|---|
| Ser 145 | - | cloning artifact |
| Met 146 | - | cloning artifact |
| Gly 229 | Asp 229 | engineered mutation |
| Ser 231 | - | cloning artifact |
| Thr 232 | - | cloning artifact |
| Arg 233 | - | cloning artifact |
| Leu 234 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 9931.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 62.1 | |
| All* | Total formula weight | 9993.4 |
