2HDK
Crystal Structure of Cys315Ala-Cys318Ala Mutant of Human Mitochondrial Branched Chain Aminotransferase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Branched-chain-amino-acid aminotransferase, mitochondrial | polymer | 365 | 41303.9 | 2 | UniProt (O15382) Pfam (PF01063) | Homo sapiens (human) | BCATm, Placental protein 18, PP18, Mitochondrial Branched Chain Aminotransferase |
| 2 | C, E (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 3 | D (A) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 4 | F (B) | 2-OXO-4-METHYLPENTANOIC ACID | non-polymer | 130.1 | 1 | Chemie (COI) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 365 (UniProt: O15382)
| PDB | External Database | Details |
|---|---|---|
| Arg 159 | Thr 186 | conflict |
| Ala 315 | Cys 342 | engineered mutation |
| Ala 318 | Cys 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82607.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 684.5 | |
| All* | Total formula weight | 83292.3 |
