2HCR
crystal structure of human phosphoribosyl pyrophosphate synthetase 1 in complex with AMP(ATP), cadmium and sulfate ion
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ribose-phosphate pyrophosphokinase I | polymer | 326 | 35950.4 | 2 | UniProt (P60891) Pfam (PF13793) Pfam (PF14572) | Homo sapiens (human) | Phosphoribosyl pyrophosphate synthetase I, PRS-I, PPRibP, PRPP synthetase 1 |
| 2 | C, D, E, H, I... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | F, K (A, B) | CADMIUM ION | non-polymer | 112.4 | 2 | Chemie (CD) | |||
| 4 | G, L (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 318 (UniProt: P60891)
| PDB | External Database | Details |
|---|---|---|
| Leu 319 | - | expression tag |
| Glu 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
| His 324 | - | expression tag |
| His 325 | - | expression tag |
| His 326 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71900.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1495.6 | |
| All* | Total formula weight | 73396.4 |
