2HCR

crystal structure of human phosphoribosyl pyrophosphate synthetase 1 in complex with AMP(ATP), cadmium and sulfate ion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ribose-phosphate pyrophosphokinase I	polymer	326	35950.4	2	UniProt (P60891) Pfam (PF13793) Pfam (PF14572)	Homo sapiens (human)	Phosphoribosyl pyrophosphate synthetase I, PRS-I, PPRibP, PRPP synthetase 1
2	C, D, E, H, I... (A, B)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
3	F, K (A, B)	CADMIUM ION	non-polymer		112.4	2	Chemie (CD) PubChem (31193)
4	G, L (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505)
5	M, N (A, B)	water	water		18.0	144	Chemie (HOH)

Sequence modifications

A, B: 1 - 318 (UniProt: P60891)

PDB	External Database	Details
Leu 319	-	expression tag
Glu 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71900.8
Non-Polymers*	Number of molecules	10
	Total formula weight	1495.6
All*	Total formula weight	73396.4

*Water molecules are not included.