2HCR
crystal structure of human phosphoribosyl pyrophosphate synthetase 1 in complex with AMP(ATP), cadmium and sulfate ion
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0002189 | cellular_component | ribose phosphate diphosphokinase complex |
| A | 0004749 | molecular_function | ribose phosphate diphosphokinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006015 | biological_process | 5-phosphoribose 1-diphosphate biosynthetic process |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0007399 | biological_process | nervous system development |
| A | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0034418 | biological_process | urate biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046101 | biological_process | hypoxanthine biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0002189 | cellular_component | ribose phosphate diphosphokinase complex |
| B | 0004749 | molecular_function | ribose phosphate diphosphokinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006015 | biological_process | 5-phosphoribose 1-diphosphate biosynthetic process |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0007399 | biological_process | nervous system development |
| B | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0034418 | biological_process | urate biosynthetic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046101 | biological_process | hypoxanthine biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | SER47 |
| A | ARG49 |
| A | SER308 |
| A | VAL309 |
| A | SER310 |
| A | HOH3004 |
| A | HOH3029 |
| B | ARG104 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1002 |
| Chain | Residue |
| B | SER47 |
| B | ARG49 |
| B | SER308 |
| B | VAL309 |
| B | SER310 |
| B | HOH3004 |
| A | ARG104 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1003 |
| Chain | Residue |
| B | ASP224 |
| B | THR225 |
| B | CYS226 |
| B | GLY227 |
| B | THR228 |
| B | HOH3040 |
| B | HOH3071 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | ASP224 |
| A | THR225 |
| A | CYS226 |
| A | GLY227 |
| A | THR228 |
| A | HOH3050 |
| A | HOH3054 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1005 |
| Chain | Residue |
| A | LYS99 |
| A | LYS100 |
| A | ASP101 |
| A | LYS102 |
| B | SER132 |
| B | GLN135 |
| B | ASN144 |
| B | TYR146 |
| B | HOH3079 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | SER132 |
| A | GLN135 |
| A | ASN144 |
| A | TYR146 |
| A | HOH3003 |
| B | LYS99 |
| B | LYS100 |
| B | ASP101 |
| B | LYS102 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD B 2001 |
| Chain | Residue |
| B | ASP171 |
| B | ASP220 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 2002 |
| Chain | Residue |
| A | ASP171 |
| A | ASP220 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AMP A 3001 |
| Chain | Residue |
| A | ARG96 |
| A | GLN97 |
| A | LYS99 |
| A | HIS130 |
| B | PHE35 |
| B | ASN37 |
| B | GLU39 |
| B | LYS176 |
| B | HOH3053 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE AMP B 3002 |
| Chain | Residue |
| A | PHE35 |
| A | ASN37 |
| A | GLU39 |
| A | LYS176 |
| B | ARG96 |
| B | GLN97 |
| B | ASP101 |
| B | HIS130 |
Functional Information from PROSITE/UniProt
| site_id | PS00114 |
| Number of Residues | 16 |
| Details | PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAsQIQGFFdiPVD |
| Chain | Residue | Details |
| A | ASP128-ASP143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Region: {"description":"Binding of phosphoribosylpyrophosphate","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
