2H7F
Structure of variola topoisomerase covalently bound to DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Y) | 5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3' | polymer | 11 | 3291.1 | 1 | |||
| 2 | B (Z) | 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3' | polymer | 14 | 4337.9 | 1 | |||
| 3 | C (X) | DNA topoisomerase 1 | polymer | 314 | 36697.4 | 1 | UniProt (P32989) Pfam (PF09266) Pfam (PF01028) | Variola virus | DNA topoisomerase I |
| 4 | D, E, F (Y, Z, X) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
X: 1 - 314 (UniProt: P32989)
| PDB | External Database | Details |
|---|---|---|
| Ser 100 | Cys 100 | engineered mutation |
| Ser 211 | Cys 211 | engineered mutation |
| Ptr 274 | Tyr 274 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44326.4 | |
| All* | Total formula weight | 44326.4 |
