2H7F

Structure of variola topoisomerase covalently bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0003677	molecular_function	DNA binding
X	0003916	molecular_function	DNA topoisomerase activity
X	0003917	molecular_function	DNA topoisomerase type I (single strand cut, ATP-independent) activity
X	0006265	biological_process	DNA topological change
X	0044423	cellular_component	virion component

Functional Information from PROSITE/UniProt

site_id	PS00176
Number of Residues	19
Details	TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EvvghtpSISKraYMattI

Chain	Residue	Details
X	GLU261-ILE279

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000269|PubMed:16885024

Chain	Residue	Details
X	PTR274

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Involved in religation => ECO:0000305|PubMed:16885024

Chain	Residue	Details
X	ASP168

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