2H59
Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | NAD-dependent deacetylase | polymer | 246 | 27502.7 | 2 | UniProt (Q9WYW0) Pfam (PF02146) In PDB | Thermotoga maritima | Regulatory protein SIR2 homolog |
| 2 | D, E | Cellular tumor antigen p53 | polymer | 18 | 2098.5 | 2 | UniProt (Q9NP68) UniProt (by SIFTS) (P04637) In PDB | Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13 | |
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A | ADENOSINE-5-DIPHOSPHORIBOSE | non-polymer | 559.3 | 1 | Chemie (APR) | |||
| 5 | B | (2S,3S,4R,5S)-2-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-4,5-DIHYDROXYTETRAHYDROFURAN-3-YL ACETATE | non-polymer | 601.4 | 1 | Chemie (3OD) | |||
| 6 | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 246 (UniProt: Q9WYW0)
| PDB | External Database | Details |
|---|---|---|
| Ala 116 | His 116 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59202.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1291.5 | |
| All* | Total formula weight | 60493.9 |
