2H59
Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | CYS124 |
| A | CYS127 |
| A | CYS148 |
| A | CYS151 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1001 |
| Chain | Residue |
| B | CYS124 |
| B | CYS127 |
| B | CYS148 |
| B | CYS151 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE APR A 252 |
| Chain | Residue |
| A | ALA22 |
| A | GLY23 |
| A | THR26 |
| A | PRO27 |
| A | ASP32 |
| A | PHE33 |
| A | ARG34 |
| A | TYR40 |
| A | GLN98 |
| A | PHE162 |
| A | GLY188 |
| A | SER189 |
| A | SER190 |
| A | VAL193 |
| A | ASN214 |
| A | LEU215 |
| A | MET230 |
| A | ASP231 |
| A | VAL232 |
| A | HOH1009 |
| A | HOH1042 |
| A | HOH1058 |
| A | HOH1064 |
| A | HOH1089 |
| A | HOH1102 |
| D | LYS11 |
| A | GLY21 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE 3OD B 253 |
| Chain | Residue |
| B | GLY21 |
| B | ALA22 |
| B | GLY23 |
| B | THR26 |
| B | PRO27 |
| B | ASP32 |
| B | PHE33 |
| B | ARG34 |
| B | TYR40 |
| B | GLN98 |
| B | ALA116 |
| B | PHE162 |
| B | GLY188 |
| B | SER189 |
| B | SER190 |
| B | VAL193 |
| B | ASN214 |
| B | LEU215 |
| B | MET230 |
| B | ASP231 |
| B | VAL232 |
| B | HOH1003 |
| B | HOH1006 |
| B | HOH1035 |
| B | HOH1053 |
| B | HOH1075 |
| E | LYS11 |
| E | HOH192 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 490 |
| Details | Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4F","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15780941","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YC5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15780941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16768447","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18786399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19801667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21080423","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2H2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2H4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JR3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PDH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"29474172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; by KMT5A; alternate","evidences":[{"source":"PubMed","id":"17707234","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20870725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22864287","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
