2GWS
Crystal Structure of human DNA Polymerase lambda with a G/G mismatch in the primer terminus
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (T, F, J, N) | 5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3' | polymer | 11 | 3344.2 | 4 | |||
| 2 | B, E, H, K (P, G, K, R) | 5'-D(*GP*TP*GP*CP*GP*G)-3' | polymer | 6 | 1865.2 | 4 | |||
| 3 | C, F, I, L (D, H, L, Q) | 5'-D(P*GP*CP*CP*G)-3' | polymer | 4 | 1191.8 | 4 | |||
| 4 | M, N, O, P (A, E, I, M) | DNA polymerase lambda | polymer | 335 | 37479.8 | 4 | UniProt (Q9UGP5) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (human) | Pol Lambda, DNA polymerase kappa, DNA polymerase beta-2, Pol beta2 |
| 5 | AA, CA, DA, EA, Q... (E, I, M, T, P...) | SODIUM ION | non-polymer | 23.0 | 8 | Chemie (NA) | |||
| 6 | S, U, V (D, H, J) | CACODYLATE ION | non-polymer | 137.0 | 3 | Chemie (CAC) | |||
| 7 | T (F) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 8 | BA, W (E, N) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 9 | Z (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 10 | FA, GA, HA, IA, JA... (T, P, D, F, G...) | water | water | 18.0 | 799 | Chemie (HOH) |
Sequence modifications
A, E, I, M: 242 - 575 (UniProt: Q9UGP5)
| PDB | External Database | Details |
|---|---|---|
| Met 241 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 175524.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 778.8 | |
| All* | Total formula weight | 176302.8 |
