2GWS

Crystal Structure of human DNA Polymerase lambda with a G/G mismatch in the primer terminus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0006281	biological_process	DNA repair
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034061	molecular_function	DNA polymerase activity
I	0003677	molecular_function	DNA binding
I	0003887	molecular_function	DNA-directed DNA polymerase activity
I	0006281	biological_process	DNA repair
I	0016779	molecular_function	nucleotidyltransferase activity
I	0034061	molecular_function	DNA polymerase activity
M	0003677	molecular_function	DNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0006281	biological_process	DNA repair
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 940

Chain	Residue
A	SER339
A	ILE341
A	ALA344
A	HOH959
P	DG5
P	HOH423

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 941

Chain	Residue
E	HOH2821
G	DG5
G	HOH262
E	SER339
E	ILE341
E	ALA344

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA I 942

Chain	Residue
I	SER339
I	ILE341
I	ALA344
K	DG5
K	HOH648

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA M 943

Chain	Residue
M	SER339
M	ILE341
M	ALA344
M	HOH1033
R	DG5
R	HOH33

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA T 944

Chain	Residue
D	HOH634
T	HOH631
T	HOH632
T	HOH633
T	HOH635
T	HOH636

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA P 945

Chain	Residue
P	DG5
P	DG6
P	HOH282
T	DG6
T	HOH507
T	HOH568

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG F 946

Chain	Residue
F	DG2
F	DG3
F	HOH754
F	HOH756
F	HOH757
F	HOH758
F	HOH759
H	HOH755

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA M 947

Chain	Residue
M	ASN340
M	HOH1033

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA Q 948

Chain	Residue
N	HOH2834
N	HOH2835
Q	HOH805

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CAC D 949

Chain	Residue
D	DC3
D	DG4
N	DC1
Q	DC3
Q	DG4

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CAC H 950

Chain	Residue
H	DG4

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CAC J 951

Chain	Residue
J	DG2
J	DG3
L	DG1

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 952

Chain	Residue
A	THR555
A	GLU556

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO N 2801

Chain	Residue
M	TYR505
M	HOH1014
N	DA5
R	DG6

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	224
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
A	ASP490

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
E	ASP490

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
I	ASP490

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
M	ASP490

---