2GVD
Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With TNP-ATP and Mn
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Adenylate cyclase type 5 | polymer | 225 | 25526.5 | 1 | UniProt (P30803) Pfam (PF00211) In PDB | Canis lupus familiaris (dog) | Adenylate cyclase type V, ATP pyrophosphate-lyase 5, Adenylyl cyclase 5, Ca2+, -inhibitable adenylyl cyclase |
2 | B | Adenylate cyclase type 2 | polymer | 212 | 23717.0 | 1 | UniProt (P26769) Pfam (PF00211) In PDB | Rattus norvegicus (Norway rat) | Adenylate cyclase type II, ATP pyrophosphate-lyase 2, Adenylyl cyclase 2 |
3 | C | Guanine nucleotide-binding protein G(s), alpha subunit | polymer | 394 | 45769.5 | 1 | UniProt (P04896) Pfam (PF00503) In PDB | Bos taurus (cattle) | Adenylate cyclase-stimulating G alpha protein |
4 | A, C | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
5 | A | METHYLPIPERAZINOFORSKOLIN | non-polymer | 550.7 | 1 | Chemie (FKP) | |||
6 | A | SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE | non-polymer | 718.3 | 1 | Chemie (128) | |||
7 | C | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | C | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
9 | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 363 - 580 (UniProt: P30803)
PDB | External Database | Details |
---|---|---|
Met 476 | Val 557 | engineered mutation |
Met 356 | - | initiating methionine |
His 357 | - | expression tag |
His 358 | - | expression tag |
His 359 | - | expression tag |
His 360 | - | expression tag |
His 361 | - | expression tag |
His 362 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 95013.1 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2008.5 | |
All* | Total formula weight | 97021.6 |