2FTO
Y94F mutant of thymidylate synthase bound to thymidine-5'-phosphate and 10-propargyl-5,8-dideazafolid acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Thymidylate synthase | polymer | 264 | 30543.7 | 1 | UniProt (P0A884) Pfam (PF00303) | Escherichia coli | TS, TSase |
| 2 | B, C (X) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) PubChem (1061) | |||
| 3 | D (X) | THYMIDINE-5'-PHOSPHATE | non-polymer | 322.2 | 1 | Chemie (TMP) PubChem (18531120) PubChem (20711568) PubChem (1139) PubChem (23657880) PubChem (24802545) PubChem (444919) PubChem (44361457) PubChem (25113134) PubChem (51397487) PubChem (5748250) PubChem (9700) PubChem (10147784) PubChem (5274091) PubChem (129069890) PubChem (133126478) PubChem (164603144) | |||
| 4 | E (X) | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 1 | Chemie (CB3) | |||
| 5 | F (X) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
X: 1 - 264 (UniProt: P0A884)
| PDB | External Database | Details |
|---|---|---|
| Cxm 1 | Met 1 | modified residue |
| Phe 94 | Tyr 94 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30543.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 989.6 | |
| All* | Total formula weight | 31533.3 |
