2FTO
Y94F mutant of thymidylate synthase bound to thymidine-5'-phosphate and 10-propargyl-5,8-dideazafolid acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Thymidylate synthase | polymer | 264 | 30543.7 | 1 | UniProt (P0A884) Pfam (PF00303) | Escherichia coli | TS, TSase |
| 2 | B, C (X) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | D (X) | THYMIDINE-5'-PHOSPHATE | non-polymer | 322.2 | 1 | Chemie (TMP) | |||
| 4 | E (X) | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 1 | Chemie (CB3) | |||
| 5 | F (X) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
X: 1 - 264 (UniProt: P0A884)
| PDB | External Database | Details |
|---|---|---|
| Cxm 1 | Met 1 | modified residue |
| Phe 94 | Tyr 94 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30543.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 989.6 | |
| All* | Total formula weight | 31533.3 |
