2FSZ
A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor beta | polymer | 246 | 27743.8 | 2 | UniProt (Q92731) Pfam (PF00104) | Homo sapiens (human) | ER-beta |
| 2 | C, D, E, F (A, B) | 4-HYDROXYTAMOXIFEN | non-polymer | 387.5 | 4 | Chemie (OHT) | |||
| 3 | G, H (A, B) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 257 - 502 (UniProt: Q92731)
| PDB | External Database | Details |
|---|---|---|
| Ser 334 | Cys 334 | engineered mutation |
| Ser 369 | Cys 369 | engineered mutation |
| Ser 481 | Cys 481 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55487.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1550.1 | |
| All* | Total formula weight | 57037.6 |
