2FF6

Crystal structure of Gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	G	Gelsolin	polymer	150	16868.0	1	UniProt (P06396) Pfam (PF00626) In PDB	Homo sapiens (human)	Actin-depolymerizing factor, ADF, Brevin, AGEL
2	H	CG4944-PC, isoform C	polymer	26	3093.3	1	UniProt (Q8IRS7) Pfam (PF01290) In PDB	Drosophila melanogaster (fruit fly)
3	A	Actin, alpha skeletal muscle	polymer	375	41862.6	1	UniProt (P68135) Pfam (PF00022) In PDB	Oryctolagus cuniculus (rabbit)	Alpha-actin-1
4	G, A	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
5	A	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
6		water	water		18.0	277	Chemie (HOH)

Sequence modifications

G: 25 - 152 (UniProt: P06396)

PDB	External Database	Details
Met 3	-	EXPRESSION TAG
Lys 4	-	EXPRESSION TAG
His 5	-	EXPRESSION TAG
His 6	-	EXPRESSION TAG
His 7	-	EXPRESSION TAG
His 8	-	EXPRESSION TAG
His 9	-	EXPRESSION TAG
His 10	-	EXPRESSION TAG
His 11	-	EXPRESSION TAG
His 12	-	EXPRESSION TAG
Gly 13	-	EXPRESSION TAG
Gly 14	-	EXPRESSION TAG
Leu 15	-	EXPRESSION TAG
Val 16	-	EXPRESSION TAG
Pro 17	-	EXPRESSION TAG
Arg 18	-	EXPRESSION TAG
Gly 19	-	EXPRESSION TAG
Ser 20	-	EXPRESSION TAG
His 21	-	EXPRESSION TAG
Gly 22	-	EXPRESSION TAG
Gly 23	-	EXPRESSION TAG
Ser 24	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	61823.9
Non-Polymers*	Number of molecules	4
	Total formula weight	627.4
All*	Total formula weight	62451.3

*Water molecules are not included.