2EUF
X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | viral Cyclin | polymer | 254 | 28665.4 | 1 | UniProt (Q01043) Pfam (PF00134) Pfam (PF09241) In PDB | Herpesvirus saimiri (strain 11) | V-cyclin |
2 | B | Cell division protein kinase 6 | polymer | 308 | 35066.3 | 1 | UniProt (Q00534) Pfam (PF00069) In PDB | Homo sapiens (human) | CDK6, Serine/threonine-protein kinase PLSTIRE |
3 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
4 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
5 | B | 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | non-polymer | 447.5 | 1 | Chemie (LQQ) | |||
6 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
7 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 63731.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 624.8 | |
All* | Total formula weight | 64356.5 |