2EUF
X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0044071 | biological_process | symbiont-mediated perturbation of host cell cycle progression |
| A | 0051301 | biological_process | cell division |
| B | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000307 | cellular_component | cyclin-dependent protein kinase holoenzyme complex |
| B | 0001726 | cellular_component | ruffle |
| B | 0001954 | biological_process | positive regulation of cell-matrix adhesion |
| B | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
| B | 0003323 | biological_process | type B pancreatic cell development |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004693 | molecular_function | cyclin-dependent protein serine/threonine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005813 | cellular_component | centrosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006974 | biological_process | DNA damage response |
| B | 0007165 | biological_process | signal transduction |
| B | 0007219 | biological_process | Notch signaling pathway |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0009615 | biological_process | response to virus |
| B | 0010389 | biological_process | regulation of G2/M transition of mitotic cell cycle |
| B | 0010468 | biological_process | regulation of gene expression |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0014002 | biological_process | astrocyte development |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0021542 | biological_process | dentate gyrus development |
| B | 0021670 | biological_process | lateral ventricle development |
| B | 0030097 | biological_process | hemopoiesis |
| B | 0030154 | biological_process | cell differentiation |
| B | 0030332 | molecular_function | cyclin binding |
| B | 0033077 | biological_process | T cell differentiation in thymus |
| B | 0042063 | biological_process | gliogenesis |
| B | 0042127 | biological_process | regulation of cell population proliferation |
| B | 0043697 | biological_process | cell dedifferentiation |
| B | 0045596 | biological_process | negative regulation of cell differentiation |
| B | 0045638 | biological_process | negative regulation of myeloid cell differentiation |
| B | 0045646 | biological_process | regulation of erythrocyte differentiation |
| B | 0045656 | biological_process | negative regulation of monocyte differentiation |
| B | 0045668 | biological_process | negative regulation of osteoblast differentiation |
| B | 0045786 | biological_process | negative regulation of cell cycle |
| B | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| B | 0048699 | biological_process | generation of neurons |
| B | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| B | 0051301 | biological_process | cell division |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0060218 | biological_process | hematopoietic stem cell differentiation |
| B | 0097131 | cellular_component | cyclin D1-CDK6 complex |
| B | 0097132 | cellular_component | cyclin D2-CDK6 complex |
| B | 0097133 | cellular_component | cyclin D3-CDK6 complex |
| B | 0098770 | molecular_function | FBXO family protein binding |
| B | 0106310 | molecular_function | protein serine kinase activity |
| B | 1902036 | biological_process | regulation of hematopoietic stem cell differentiation |
| B | 2000145 | biological_process | regulation of cell motility |
| B | 2000773 | biological_process | negative regulation of cellular senescence |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA A 255 |
| Chain | Residue |
| A | THR110 |
| A | LYS112 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT B 309 |
| Chain | Residue |
| B | ALA167 |
| B | HIS143 |
| B | ARG144 |
| B | ASP145 |
| B | ASP163 |
| B | PHE164 |
| B | GLY165 |
| B | LEU166 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LQQ B 401 |
| Chain | Residue |
| B | ILE19 |
| B | VAL77 |
| B | PHE98 |
| B | GLU99 |
| B | VAL101 |
| B | ASP102 |
| B | GLN103 |
| B | THR107 |
| B | GLN149 |
| B | LEU152 |
| B | ALA162 |
| B | ASP163 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS B 402 |
| Chain | Residue |
| B | LEU68 |
| B | GLU69 |
| B | GLU72 |
| B | HIS73 |
| B | VAL76 |
| B | VAL77 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGKVFkArdlknggrf.........VALK |
| Chain | Residue | Details |
| B | ILE19-LYS43 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpqNILV |
| Chain | Residue | Details |
| B | VAL141-VAL153 |
| site_id | PS00292 |
| Number of Residues | 32 |
| Details | CYCLINS Cyclins signature. RtiLltWMhllcesfeLdksvFplSVsILDRY |
| Chain | Residue | Details |
| A | ARG52-TYR83 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"11828325","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP145 | |
| B | GLN149 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP145 | |
| B | LYS147 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP145 | |
| B | THR182 | |
| B | LYS147 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP145 | |
| B | LYS147 | |
| B | ASN150 |
