2ERJ
Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Interleukin-2 receptor alpha chain | polymer | 225 | 25402.4 | 2 | UniProt (P01589) Pfam (PF00084) In PDB | Homo sapiens (human) | IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, p55, CD25, TAC antigen |
2 | B, F | Interleukin-2 receptor beta chain | polymer | 219 | 25452.9 | 2 | UniProt (P14784) Pfam (PF18707) In PDB | Homo sapiens (human) | IL-2 receptor beta subunit, IL-2-RB, p75, CD122 |
3 | C, G | Cytokine receptor common gamma chain | polymer | 247 | 29169.5 | 2 | UniProt (P31785) Pfam (PF21604) Pfam (PF21605) In PDB | Homo sapiens (human) | IL-2 receptor Gamma subunit, IL-2-RG, p65, CD132 |
4 | D, H | Interleukin-2 | polymer | 133 | 15403.9 | 2 | UniProt (P60568) Pfam (PF00715) In PDB | Homo sapiens (human) | IL-2, T-cell growth factor, TCGF, Aldesleukin |
5 | I, M | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
6 | J | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
7 | K, O | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
8 | L, P | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
9 | N | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
10 | C, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, E: 1 - 212 (UniProt: P01589)
B, F: 1 - 206 (UniProt: P14784)
C, G: 1 - 233 (UniProt: P31785)
D, H: 1 - 133 (UniProt: P60568)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | cloning artifact |
Met -3 | - | cloning artifact |
Leu -2 | - | cloning artifact |
Ser -1 | - | cloning artifact |
Leu 0 | - | cloning artifact |
Ser 49 | Asn 70 | engineered mutation |
Ser 68 | Asn 89 | engineered mutation |
Thr 213 | - | expression tag |
Gly 214 | - | expression tag |
His 215 | - | expression tag |
His 216 | - | expression tag |
His 217 | - | expression tag |
His 218 | - | expression tag |
His 219 | - | expression tag |
His 220 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -4 | - | cloning artifact |
Met -3 | - | cloning artifact |
Leu -2 | - | cloning artifact |
Ser -1 | - | cloning artifact |
Leu 0 | - | cloning artifact |
Thr 207 | - | expression tag |
Gly 208 | - | expression tag |
His 209 | - | expression tag |
His 210 | - | expression tag |
His 211 | - | expression tag |
His 212 | - | expression tag |
His 213 | - | expression tag |
His 214 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -4 | - | cloning artifact |
Met -3 | - | cloning artifact |
Leu -2 | - | cloning artifact |
Ser -1 | - | cloning artifact |
Leu 0 | - | cloning artifact |
Gln 53 | Asn 75 | engineered mutation |
Arg 234 | - | expression tag |
Thr 235 | - | expression tag |
Gly 236 | - | expression tag |
His 237 | - | expression tag |
His 238 | - | expression tag |
His 239 | - | expression tag |
His 240 | - | expression tag |
His 241 | - | expression tag |
His 242 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 125 | Cys 145 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 190857.5 | |
Branched | Number of molecules | 8 |
Total formula weight | 4425.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 884.8 | |
All* | Total formula weight | 196167.4 |