Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2ERJ

Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004911	molecular_function	interleukin-2 receptor activity
A	0019976	molecular_function	interleukin-2 binding
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
D	0001933	biological_process	negative regulation of protein phosphorylation
D	0001934	biological_process	positive regulation of protein phosphorylation
D	0002250	biological_process	adaptive immune response
D	0002366	biological_process	leukocyte activation involved in immune response
D	0002639	biological_process	positive regulation of immunoglobulin production
D	0002903	biological_process	negative regulation of B cell apoptotic process
D	0005125	molecular_function	cytokine activity
D	0005134	molecular_function	interleukin-2 receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006366	biological_process	transcription by RNA polymerase II
D	0006955	biological_process	immune response
D	0007155	biological_process	cell adhesion
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
D	0007267	biological_process	cell-cell signaling
D	0008083	molecular_function	growth factor activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0010467	biological_process	gene expression
D	0019209	molecular_function	kinase activator activity
D	0030101	biological_process	natural killer cell activation
D	0030217	biological_process	T cell differentiation
D	0030246	molecular_function	carbohydrate binding
D	0030307	biological_process	positive regulation of cell growth
D	0030890	biological_process	positive regulation of B cell proliferation
D	0031851	molecular_function	kappa-type opioid receptor binding
D	0032729	biological_process	positive regulation of type II interferon production
D	0032740	biological_process	positive regulation of interleukin-17 production
D	0034105	biological_process	positive regulation of tissue remodeling
D	0038110	biological_process	interleukin-2-mediated signaling pathway
D	0042098	biological_process	T cell proliferation
D	0042102	biological_process	positive regulation of T cell proliferation
D	0042104	biological_process	positive regulation of activated T cell proliferation
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0043066	biological_process	negative regulation of apoptotic process
D	0043208	molecular_function	glycosphingolipid binding
D	0045471	biological_process	response to ethanol
D	0045582	biological_process	positive regulation of T cell differentiation
D	0045591	biological_process	positive regulation of regulatory T cell differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046013	biological_process	regulation of T cell homeostatic proliferation
D	0046651	biological_process	lymphocyte proliferation
D	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
D	0050672	biological_process	negative regulation of lymphocyte proliferation
D	0050728	biological_process	negative regulation of inflammatory response
D	0050729	biological_process	positive regulation of inflammatory response
D	0050798	biological_process	activated T cell proliferation
D	0060999	biological_process	positive regulation of dendritic spine development
D	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
D	1900100	biological_process	positive regulation of plasma cell differentiation
D	1901327	biological_process	response to tacrolimus
D	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
D	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
E	0004911	molecular_function	interleukin-2 receptor activity
E	0019976	molecular_function	interleukin-2 binding
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane
G	0004896	molecular_function	cytokine receptor activity
G	0016020	cellular_component	membrane
H	0001933	biological_process	negative regulation of protein phosphorylation
H	0001934	biological_process	positive regulation of protein phosphorylation
H	0002250	biological_process	adaptive immune response
H	0002366	biological_process	leukocyte activation involved in immune response
H	0002639	biological_process	positive regulation of immunoglobulin production
H	0002903	biological_process	negative regulation of B cell apoptotic process
H	0005125	molecular_function	cytokine activity
H	0005134	molecular_function	interleukin-2 receptor binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006366	biological_process	transcription by RNA polymerase II
H	0006955	biological_process	immune response
H	0007155	biological_process	cell adhesion
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
H	0007205	biological_process	protein kinase C-activating G protein-coupled receptor signaling pathway
H	0007267	biological_process	cell-cell signaling
H	0008083	molecular_function	growth factor activity
H	0008284	biological_process	positive regulation of cell population proliferation
H	0010467	biological_process	gene expression
H	0019209	molecular_function	kinase activator activity
H	0030101	biological_process	natural killer cell activation
H	0030217	biological_process	T cell differentiation
H	0030246	molecular_function	carbohydrate binding
H	0030307	biological_process	positive regulation of cell growth
H	0030890	biological_process	positive regulation of B cell proliferation
H	0031851	molecular_function	kappa-type opioid receptor binding
H	0032729	biological_process	positive regulation of type II interferon production
H	0032740	biological_process	positive regulation of interleukin-17 production
H	0034105	biological_process	positive regulation of tissue remodeling
H	0038110	biological_process	interleukin-2-mediated signaling pathway
H	0042098	biological_process	T cell proliferation
H	0042102	biological_process	positive regulation of T cell proliferation
H	0042104	biological_process	positive regulation of activated T cell proliferation
H	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
H	0043066	biological_process	negative regulation of apoptotic process
H	0043208	molecular_function	glycosphingolipid binding
H	0045471	biological_process	response to ethanol
H	0045582	biological_process	positive regulation of T cell differentiation
H	0045591	biological_process	positive regulation of regulatory T cell differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046013	biological_process	regulation of T cell homeostatic proliferation
H	0046651	biological_process	lymphocyte proliferation
H	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
H	0050672	biological_process	negative regulation of lymphocyte proliferation
H	0050728	biological_process	negative regulation of inflammatory response
H	0050729	biological_process	positive regulation of inflammatory response
H	0050798	biological_process	activated T cell proliferation
H	0060999	biological_process	positive regulation of dendritic spine development
H	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
H	1900100	biological_process	positive regulation of plasma cell differentiation
H	1901327	biological_process	response to tacrolimus
H	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
H	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS01355
Number of Residues	34
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. VdgqkrytfrVRsrfnplcgsaqh........WSeWShpihW

Chain	Residue	Details
C	VAL191-TRP224
B	LEU172-PHE203

site_id	PS00424
Number of Residues	13
Details	INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL

Chain	Residue	Details
D	THR51-LEU63

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269\|PubMed:2793860, ECO:0000269\|PubMed:6333684

Chain	Residue	Details
D	THR3
H	THR3
C	ASN227
G	ASN2
G	GLN53
G	ASN227

site_id	SWS_FT_FI2
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16293754, ECO:0000269\|PubMed:16477002

Chain	Residue	Details
C	ASN49
C	ASN62
C	ASN137
G	ASN49
G	ASN62
G	ASN137

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16293754, ECO:0000269\|PubMed:16477002

Chain	Residue	Details
B	SER125
F	SER125

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)