2CJZ

crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5	polymer	305	35188.8	1	UniProt (P54829) Pfam (PF00102) In PDB	HOMO SAPIENS (HUMAN)	PROTEIN-TYROSINE PHOSPHATASE STRIATUM-ENRICHED, STEP, NEURAL- SPECIFIC PROTEIN-TYROSINE PHOSPHATASE
2	A	O-PHOSPHOTYROSINE	non-polymer		261.2	1	Chemie (PTR)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4		water	water		18.0	212	Chemie (HOH)

Sequence modifications

A: -23 - -1 (PDB: 2CJZ)
A: 258 - 539 (UniProt: P54829)

PDB	External Database	Details
Asp 289	Val 289	variant
Leu 298	Arg 298	variant
Val 299	Cys 299	variant
Ser 472	Cys 472	engineered mutation
Thr 517	His 517	variant

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35188.8
Non-Polymers*	Number of molecules	2
	Total formula weight	323.2
All*	Total formula weight	35512.0

*Water molecules are not included.