2CJZ

crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PTR A 1537

Chain	Residue
A	TYR304
A	HOH2213
A	ILE307
A	SER472
A	SER473
A	ALA474
A	GLY475
A	ILE476
A	GLY477
A	ARG478

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1538

Chain	Residue
A	PHE280
A	PHE281
A	ILE283
A	MET285
A	ARG508
A	HOH2194

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044

Chain	Residue	Details
A	GLY496

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU461
A	GLN516

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	GLY496

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK => ECO:0000269|PubMed:21777200

Chain	Residue	Details
A	GLU268

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