2C9W

CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	SUPPRESSOR OF CYTOKINE SIGNALING 2	polymer	169	19273.3	1	UniProt (O14508) Pfam (PF00017) Pfam (PF07525)	HOMO SAPIENS (HUMAN)	HUMAN SOCS2, SOCS-2, CYTOKINE-INDUCIBLE SH2 PROTEIN 2, CIS-2, STAT-INDUCED STAT INHIBITOR 2, SSI-2
2	B (B)	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2	polymer	118	13147.8	1	UniProt (Q15370) Pfam (PF00240)	HOMO SAPIENS (HUMAN)	HUMAN ELONGIN B, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18, ELONGIN B, ELOB, ELONGIN 18 KDA SUBUNIT
3	C (C)	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1	polymer	97	10974.6	1	UniProt (Q15369) Pfam (PF03931)	HOMO SAPIENS (HUMAN)	HUMAN ELONGIN C, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15, ELONGIN C, ELOC, ELONGIN 15 KDA SUBUNIT
4	D, E, F (A)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
5	G, H, I (A, B)	NICKEL (II) ION	non-polymer		58.7	3	Chemie (NI)
6	J, K, L (A, B, C)	water	water		18.0	172	Chemie (HOH)

Sequence modifications

A: 30 - 31 (PDB: 2C9W)
A: 32 - 198 (UniProt: O14508)
C: 16 - 16 (PDB: 2C9W)
C: 17 - 112 (UniProt: Q15369)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	43395.7
Non-Polymers*	Number of molecules	6
	Total formula weight	464.3
All*	Total formula weight	43859.9

*Water molecules are not included.