2C9W
CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0035556 | biological_process | intracellular signal transduction |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0000151 | cellular_component | ubiquitin ligase complex |
| B | 0001222 | molecular_function | transcription corepressor binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006367 | biological_process | transcription initiation at RNA polymerase II promoter |
| B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0030891 | cellular_component | VCB complex |
| B | 0031462 | cellular_component | Cul2-RING ubiquitin ligase complex |
| B | 0031466 | cellular_component | Cul5-RING ubiquitin ligase complex |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| B | 0065003 | biological_process | protein-containing complex assembly |
| B | 0070449 | cellular_component | elongin complex |
| B | 0140627 | biological_process | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
| B | 0140958 | biological_process | target-directed miRNA degradation |
| B | 1990116 | biological_process | ribosome-associated ubiquitin-dependent protein catabolic process |
| B | 2000104 | biological_process | negative regulation of DNA-templated DNA replication |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A1199 |
| Chain | Residue |
| A | VAL55 |
| A | ARG73 |
| A | SER75 |
| A | SER76 |
| A | THR83 |
| A | ARG96 |
| A | HOH2074 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1200 |
| Chain | Residue |
| A | ARG105 |
| A | HOH2075 |
| A | THR54 |
| A | ASN56 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A1201 |
| Chain | Residue |
| A | GLN45 |
| A | SER162 |
| A | ARG168 |
| A | TYR190 |
| A | HOH2076 |
| A | HOH2077 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI A1202 |
| Chain | Residue |
| A | ASP120 |
| A | HIS124 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI A1203 |
| Chain | Residue |
| A | CYS111 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI B1105 |
| Chain | Residue |
| B | CYS89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | Domain: {"description":"SOCS box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00194","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"31578312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"31578312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
