2BBT
Human deltaF508 NBD1 with two solublizing mutations.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Cystic fibrosis transmembrane conductance regulator | polymer | 290 | 32443.8 | 2 | UniProt (P13569) Pfam (PF00005) In PDB | Homo sapiens (human) | CFTR, cAMP-dependent chloride channel |
| 2 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | A, B | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A, B: 389 - 678 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Ser 388 | Thr 388 | cloning artifact |
| Asn 494 | Phe 494 | engineered mutation |
| - | Phe 508 | deletion |
| Arg 637 | Gln 637 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64887.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.0 | |
| All* | Total formula weight | 65950.7 |
