2BBT
Human deltaF508 NBD1 with two solublizing mutations.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 3 |
| Chain | Residue |
| A | ATP1 |
| A | HOH132 |
| A | THR465 |
| A | GLN493 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 4 |
| Chain | Residue |
| B | ATP2 |
| B | HOH116 |
| B | THR465 |
| B | GLN493 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ATP A 1 |
| Chain | Residue |
| A | HOH30 |
| A | HOH42 |
| A | HOH53 |
| A | HOH132 |
| A | TRP401 |
| A | VAL440 |
| A | THR460 |
| A | GLY461 |
| A | ALA462 |
| A | GLY463 |
| A | LYS464 |
| A | THR465 |
| A | SER466 |
| A | GLN493 |
| B | ASN597 |
| A | MG3 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ATP B 2 |
| Chain | Residue |
| B | MG4 |
| B | HOH116 |
| B | TRP401 |
| B | VAL440 |
| B | THR460 |
| B | GLY461 |
| B | ALA462 |
| B | GLY463 |
| B | LYS464 |
| B | THR465 |
| B | SER466 |
| B | GLN493 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV |
| Chain | Residue | Details |
| A | LEU548-VAL562 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15528182, ECO:0000269|PubMed:20150177, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT, ECO:0007744|PDB:2PZE, ECO:0007744|PDB:2PZF, ECO:0007744|PDB:2PZG |
| Chain | Residue | Details |
| A | TRP401 | |
| B | TRP401 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20150177, ECO:0007744|PDB:2PZE, ECO:0007744|PDB:2PZF, ECO:0007744|PDB:2PZG |
| Chain | Residue | Details |
| A | SER434 | |
| B | SER434 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT |
| Chain | Residue | Details |
| A | GLY458 | |
| B | GLY458 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS |
| Chain | Residue | Details |
| A | GLN493 | |
| B | GLN493 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | GLY550 | |
| B | GLY550 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:1377674, ECO:0000269|PubMed:22119790, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:9385646 |
| Chain | Residue | Details |
| A | ILE661 | |
| B | ILE661 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:25330774 |
| Chain | Residue | Details |
| A | LEU671 | |
| B | LEU671 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:22119790 |
| Chain | Residue | Details |
| A | GLN525 | |
| B | GLN525 |
