2AR9

Crystal structure of a dimeric caspase-9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Caspase-9	polymer	278	30553.8	4	UniProt (P55211) Pfam (PF00656) In PDB	Homo sapiens (human)
2	A	D-MALATE	non-polymer		134.1	1	Chemie (MLT)
3		water	water		18.0	133	Chemie (HOH)

Sequence modifications

A, B, C, D: 140 - 416 (UniProt: P55211)

PDB	External Database	Details
Met 139	139	initiating methionine
Ser 287	Cys 287	engineered mutation
Cys 402	Gly 402	engineered mutation
Ile 403	Cys 403	engineered mutation
Val 404	Phe 404	engineered mutation
Ser 405	Asn 405	engineered mutation
Met 406	Phe 406	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	122215.2
Non-Polymers*	Number of molecules	1
	Total formula weight	134.1
All*	Total formula weight	122349.3

*Water molecules are not included.