2AR9

Crystal structure of a dimeric caspase-9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MLT A 668

Chain	Residue
A	TRP354
A	ARG355

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Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HgaldCcvVvILSHG

Chain	Residue	Details
A	HIS224-GLY238

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS237
A	SER287
B	HIS237
B	SER287
C	HIS237
C	SER287
D	HIS237
D	SER287

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:15657060

Chain	Residue	Details
A	TYR153
B	TYR153
C	TYR153
D	TYR153

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER302
B	SER302
C	SER302
D	SER302

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER307
B	SER307
C	SER307
D	SER307

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER310
B	SER310
C	SER310
D	SER310

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site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120

Chain	Residue	Details
A	ARG355
B	ARG355
C	ARG355
D	ARG355

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
A	SER287
A	GLY238
A	HIS237
A	ARG178

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
B	SER287
B	GLY238
B	HIS237
B	ARG178

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
C	SER287
C	GLY238
C	HIS237
C	ARG178

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site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1nw9

Chain	Residue	Details
D	SER287
D	GLY238
D	HIS237
D	ARG178

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
A	ARG178	electrostatic stabiliser
A	HIS237	proton acceptor, proton donor
A	GLY238	electrostatic stabiliser
A	SER287	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
B	ARG178	electrostatic stabiliser
B	HIS237	proton acceptor, proton donor
B	GLY238	electrostatic stabiliser
B	SER287	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA3
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
C	ARG178	electrostatic stabiliser
C	HIS237	proton acceptor, proton donor
C	GLY238	electrostatic stabiliser
C	SER287	nucleofuge, nucleophile, proton acceptor, proton donor

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site_id	MCSA4
Number of Residues	4
Details	M-CSA 816

Chain	Residue	Details
D	ARG178	electrostatic stabiliser
D	HIS237	proton acceptor, proton donor
D	GLY238	electrostatic stabiliser
D	SER287	nucleofuge, nucleophile, proton acceptor, proton donor

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