2AOJ
Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | POL POLYPROTEIN | polymer | 99 | 10740.7 | 2 | UniProt (P04587) Pfam (PF00077) In PDB | Human immunodeficiency virus type 1 (BH5 ISOLATE) | RETROPEPSIN |
2 | C | PEPTIDE INHIBITOR | polymer | 12 | 1162.4 | 1 | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
4 | A | ACETIC ACID | non-polymer | 60.1 | 4 | Chemie (ACY) | |||
5 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P04587)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 75 | engineered mutation |
Ile 33 | Leu 101 | engineered mutation |
Ile 63 | Leu 131 | engineered mutation |
Ala 67 | Cys 135 | engineered mutation |
Ala 95 | Cys 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 22643.7 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 488.6 | |
All* | Total formula weight | 23132.3 |