2AOG
Crystal structure analysis of HIV-1 protease mutant V82A with a substrate analog P2-NC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 PROTEASE (RETROPEPSIN) | polymer | 99 | 10712.6 | 2 | UniProt (P04587) Pfam (PF00077) | Human immunodeficiency virus type 1 (BH5 ISOLATE) | RETROPEPSIN |
| 2 | C (A) | N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide | non-polymer | 771.0 | 1 | BIRD (PRD_000398) Chemie (2NC) | |||
| 3 | D (A) | UNKNOWN ATOM OR ION | non-polymer | 1 | Chemie (UNX) | ||||
| 4 | E, F, G, I, J (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | H (A) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 268 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P04587)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 75 | engineered mutation |
| Ile 33 | Leu 101 | engineered mutation |
| Ile 63 | Leu 131 | engineered mutation |
| Ala 67 | Cys 135 | engineered mutation |
| Ala 82 | Val 150 | engineered mutation |
| Ala 95 | Cys 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21425.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1291.5 | |
| All* | Total formula weight | 22716.8 |
