2ADF
Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Von Willebrand factor | polymer | 196 | 20790.7 | 1 | UniProt (P04275) Pfam (PF00092) | Homo sapiens (human) | vWF |
| 2 | B (H) | 82D6A3 IgG | polymer | 218 | 23652.5 | 1 | UniProt (P84751) Pfam (PF07686) Pfam (PF07654) | Mus musculus (house mouse) | |
| 3 | C (L) | 82D6A3 IgG | polymer | 209 | 23092.6 | 1 | UniProt (Q58EV6) | Mus musculus (house mouse) | |
| 4 | D (A) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 5 | E, G (H, L) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | F (H) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | H, I, J (A, H, L) | water | water | 18.0 | 442 | Chemie (HOH) |
Sequence modifications
A: 920 - 1111 (UniProt: P04275)
| PDB | External Database | Details |
|---|---|---|
| Gly 916 | - | expression tag |
| Ser 917 | - | expression tag |
| His 918 | - | expression tag |
| Met 919 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 67535.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 344.3 | |
| All* | Total formula weight | 67880.0 |
