2ADF

Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0002250	biological_process	adaptive immune response
H	0002376	biological_process	immune system process
H	0003823	molecular_function	antigen binding
H	0005576	cellular_component	extracellular region
H	0016064	biological_process	immunoglobulin mediated immune response
H	0019814	cellular_component	immunoglobulin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 1002

Chain	Residue
A	GLN1089
A	ARG1090
H	LYS51
H	SER71
H	LEU72
H	SER191

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 L 1003

Chain	Residue
L	GLN27
L	ASP28
L	HOH1079
L	HOH1089
L	HOH1138
H	PRO14
H	ASN88
H	SER118

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY A 1112

Chain	Residue
A	PHE1060
A	PHE1104
A	LYS1107
A	HOH1121
A	HOH1223

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL H 1004

Chain	Residue
H	THR93
H	GLN110
H	GLY111
H	HOH1066
H	HOH1147

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR191-HIS197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Domain: {"description":"VWFA 3; main binding site for collagens type I and III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	92
Details	Domain: {"description":"Ig-like 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"D segment","evidences":[{"source":"UniProtKB","id":"P01783","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Region: {"description":"JH2 segment","evidences":[{"source":"PubMed","id":"12414967","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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