2A19
PKR kinase domain- eIF2alpha- AMP-PNP complex.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Eukaryotic translation initiation factor 2 alpha subunit | polymer | 175 | 20553.8 | 1 | UniProt (P20459) Pfam (PF00575) Pfam (PF07541) In PDB | Saccharomyces cerevisiae (baker's yeast) | eIF-2- alpha |
2 | B, C | Interferon-induced, double-stranded RNA-activated protein kinase | polymer | 284 | 32799.6 | 2 | UniProt (P19525) Pfam (PF00069) In PDB | Homo sapiens (human) | Interferon-inducible RNA-dependent protein kinase, p68 kinase, P1/eIF-2A protein kinase |
3 | B, C | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | B, C | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
5 | C | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
6 | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A: 3 - 175 (UniProt: P20459)
B, C: 258 - 538 (UniProt: P19525)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | cloning artifact |
Ser 2 | - | cloning artifact |
PDB | External Database | Details |
---|---|---|
Gly 255 | - | cloning artifact |
Ala 256 | - | cloning artifact |
His 257 | - | cloning artifact |
- | Asp 338 | deletion |
- | Asp 339 | deletion |
- | Ser 340 | deletion |
- | Leu 341 | deletion |
- | Glu 342 | deletion |
- | Ser 343 | deletion |
- | Ser 344 | deletion |
- | Asp 345 | deletion |
- | Tyr 346 | deletion |
- | Asp 347 | deletion |
- | Pro 348 | deletion |
- | Glu 349 | deletion |
- | Asn 350 | deletion |
Asn 412 | His 412 | engineered mutation |
Tpo 446 | Thr 446 | modified residue |
Ala 551 | Cys 551 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 86152.9 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1204.6 | |
All* | Total formula weight | 87357.5 |