2A19

PKR kinase domain- eIF2alpha- AMP-PNP complex.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 1641

Chain	Residue
B	ASP432
B	ANP1640

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 1642

Chain	Residue
B	ASN419
B	ASP432
B	ANP1640

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 2642

Chain	Residue
C	ASN419
C	ASP432
C	ANP2640
C	MG2641

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 2641

Chain	Residue
C	ASP414
C	ASP432
C	ANP2640
C	MG2642

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 901

Chain	Residue
C	LYS304
C	ARG307
C	ARG413

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ANP B 1640

Chain	Residue
B	GLY279
B	VAL281
B	VAL294
B	LYS296
B	MET366
B	GLU367
B	CYS369
B	SER418
B	ASN419
B	PHE421
B	ASP432
B	MG1641
B	MG1642

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ANP C 2640

Chain	Residue
C	HOH36
C	ILE273
C	GLY274
C	VAL294
C	GLU367
C	PHE368
C	CYS369
C	PHE421
C	MG2641
C	MG2642

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGGFGQVFkAkhridgkt..........YVIK

Chain	Residue	Details
B	ILE273-LYS296

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
B	GLN427
C	GLN427

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
B	ILE273
C	ILE273

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
B	LYS296
C	LYS296

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:16179258, ECO:0000305|PubMed:31246429

Chain	Residue	Details
B	ARG445
C	ARG445

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000305|PubMed:11152499

Chain	Residue	Details
B	THR258
C	THR258

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16373505

Chain	Residue	Details
B	TYR293
C	TYR293

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11337501, ECO:0000269|PubMed:16179258

Chain	Residue	Details
B	GLN459
C	GLN459

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11337501, ECO:0000269|PubMed:20685959

Chain	Residue	Details
B	ASP464
C	ASP464

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
B	VAL469
C	VAL469

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP414
B	SER418

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP414
C	SER418

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP414
B	LYS416

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP414
C	LYS416

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP414
B	LYS416
B	THR451

---

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASN419
B	ASP414
B	LYS416

---

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN419
C	ASP414
C	LYS416

---