23BD

Caspase-4 p22/p10 and human GSDMD complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, E)	Caspase-4	polymer	185	20987.7	2	UniProt (P49662) Pfam (PF00656)	Homo sapiens (human)	Caspase-4 p22,CASP-4,ICE and Ced-3 homolog 2,ICH-2,ICE(rel)-II,Mih1,Protease TX
2	C, D (C, D)	Caspase-4	polymer	88	10424.0	2	UniProt (P49662) Pfam (PF00656)	Homo sapiens (human)	CASP-4,ICE and Ced-3 homolog 2,ICH-2,ICE(rel)-II,Mih1,Protease TX
3	E (A)	Gasdermin-D	polymer	485	52995.0	1	UniProt (P57764) Pfam (PF04598) Pfam (PF17708)	Homo sapiens (human)	Gasdermin domain-containing protein 1

Sequence modifications

B, E: 105 - 289 (UniProt: P49662)

PDB	External Database	Details
Ala 258	Cys 258	engineered mutation

A: 1 - 484 (UniProt: P57764)

PDB	External Database	Details
Ser 0	-	expression tag
Leu 281	Gly 281	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	115818.4
All*	Total formula weight	115818.4

*Water molecules are not included.